Food Science Postgraduate Program, Pharmacy School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Nutrition. 2013 Apr;29(4):625-9. doi: 10.1016/j.nut.2012.09.016. Epub 2013 Jan 5.
The association between nutritional status and inflammation was assessed in patients with colorectal cancer and to verify their association with complications during anticancer treatment. The agreement between the Subjective Global Assessment (SGA) and different nutritional assessment methods was also evaluated.
A cross-sectional, prospective, and descriptive study was performed. The nutritional status was defined by the SGA and the severity of inflammation was defined by the Glasgow Prognostic Score (GPS). The complications were classified using the Common Toxicity Criteria, version 3. Anthropometric measurements such as body mass index, triceps skinfold, midarm circumference, midarm muscle area, and adductor pollicis muscle thickness were also performed, as were handgrip strength and phase angle. The chi-square test, Fisher exact test, Spearman correlation coefficient, independent t test, analysis of variance, Gabriel test, and κ index were used for the statistical analysis. P < 0.05 was considered statistically significant.
Seventy patients with colorectal cancer (60.4 ± 14.3 y old) were included. The nutritional status according to the SGA was associated with the GPS (P < 0.05), but the SGA and GPS were not related to the presence of complications. When comparing the different nutritional assessment methods with the SGA, there were statistically significant differences.
Malnutrition is highly prevalent in patients with colorectal cancer. The nutritional status was associated with the GPS.
评估结直肠癌患者的营养状况与炎症之间的关系，并验证它们与抗癌治疗期间并发症的关系。还评估了主观整体评估（SGA）与不同营养评估方法之间的一致性。
进行了一项横断面、前瞻性和描述性研究。营养状况由 SGA 定义，炎症严重程度由格拉斯哥预后评分（GPS）定义。使用常见毒性标准，第 3 版对并发症进行分类。还进行了人体测量学测量，如体重指数、三头肌皮褶厚度、上臂中部周长、上臂中部肌肉面积和拇指内收肌厚度，以及握力和相位角。统计分析采用卡方检验、Fisher 确切检验、Spearman 相关系数、独立 t 检验、方差分析、Gabriel 检验和κ指数。P<0.05 被认为具有统计学意义。
共纳入 70 例结直肠癌患者（60.4±14.3 岁）。根据 SGA 的营养状况与 GPS 相关（P<0.05），但 SGA 和 GPS 与并发症的发生无关。当将不同的营养评估方法与 SGA 进行比较时，存在统计学差异。
结直肠癌患者中营养不良的发生率很高。营养状况与 GPS 相关。
