Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
J Bone Miner Res. 2013 Jun;28(6):1308-18. doi: 10.1002/jbmr.1860.
Compared to white women, premenopausal Chinese-American women have more plate-like trabecular (Tb) bone. It is unclear whether these findings are relevant to postmenopausal women and if there are racial differences in the deterioration of bone microarchitecture with aging. We applied individual trabecula segmentation and finite element analysis to high-resolution peripheral quantitative computed tomography images in premenopausal and postmenopausal Chinese-American and white women to quantify within-race age-related differences in Tb plate-versus-rod microarchitecture and bone stiffness. Race-menopause status interactions were assessed. Comparisons between races within menopause status were adjusted for age, height and weight. Comparisons between premenopausal and postmenopausal women were adjusted for height and weight. Adjusted analyses at the radius indicated that premenopausal Chinese-Americans had a higher plate bone volume fraction (pBV/TV), Tb plate-to-rod ratio (P-R ratio), and greater plate-plate junction densities (P-P Junc.D) versus white women (all p < 0.01), resulting in 27% higher Tb stiffness (p < 0.05). Greater cortical thickness and density (Ct.Th and Dcort) and more Tb plates led to 19% greater whole bone stiffness (p < 0.05). Postmenopausal Chinese-Americans had similar pBV/TV and P-P Junc.D, yet a higher P-R ratio versus white women. Postmenopausal Chinese-American versus white women had greater Ct.Th, Dcort, and relatively intact Tb plates, resulting in similar Tb stiffness but 12% greater whole bone stiffness (p < 0.05). In both races, Ct.Th and Dcort were lower in postmenopausal versus premenopausal women and there were no differences between races. Tb plate parameters were also lower in postmenopausal versus premenopausal women, but age-related differences in pBV/TV, P-R ratio, and P-P Junc D were greater (p < 0.05) in Chinese-Americans versus white women. There are advantages in cortical and Tb bone in premenopausal Chinese-American women. Within-race cross-sectional differences between premenopausal and postmenopausal women suggest greater loss of plate-like Tb bone with aging in Chinese-Americans, though thicker cortices and more plate-like Tb bone persists.
与白人女性相比，绝经前的华裔美国女性拥有更多板状的小梁（Tb）骨。目前尚不清楚这些发现是否与绝经后女性有关，以及随着年龄的增长，骨微观结构的恶化是否存在种族差异。我们应用个体小梁分割和有限元分析方法对绝经前和绝经后华裔美国人和白人女性的高分辨率外周定量 CT 图像进行分析，以量化种族内与年龄相关的 Tb 板状与杆状微观结构和骨刚度的差异。评估了种族-绝经状态的相互作用。在绝经状态下，对不同种族之间的比较进行了年龄、身高和体重的调整。绝经前和绝经后女性之间的比较调整了身高和体重。桡骨的调整分析表明，与白人女性相比，绝经前的华裔美国人具有更高的板骨体积分数（pBV/TV）、Tb 板与杆比（P-R 比）和更大的板-板连接密度（P-P Junc.D）（均 p<0.01），导致 Tb 刚度增加 27%（p<0.05）。更大的皮质厚度和密度（Ct.Th 和 Dcort）和更多的 Tb 板导致整体骨刚度增加 19%（p<0.05）。绝经后的华裔美国人具有相似的 pBV/TV 和 P-P Junc.D，但 P-R 比值高于白人女性。与白人女性相比，绝经后的华裔美国女性具有更大的 Ct.Th、Dcort 和相对完整的 Tb 板，导致 Tb 刚度相似，但整体骨刚度增加 12%（p<0.05）。在两个种族中，绝经后女性的 Ct.Th 和 Dcort 均低于绝经前女性，且种族间无差异。与绝经前女性相比，Tb 板参数也较低，但华裔美国女性的 pBV/TV、P-R 比和 P-P Junc D 的年龄相关性差异更大（p<0.05）。绝经前的华裔美国女性在皮质和 Tb 骨方面具有优势。绝经前和绝经后女性的种族内横断面差异表明，随着年龄的增长，华裔美国人板状 Tb 骨的丢失更多，尽管皮质更厚且板状 Tb 骨更多。
