Faheem Mohammad, Mahmood Humera, Khurram Mohammad, Qasim Uzma, Irfan Javaid
Oncology Department of Nuclear Medicine, Oncology & Radiotherapy Institute (NORI), Islamabad, Pakistan.
Ecancermedicalscience. 2012;6:283. doi: 10.3332/ecancer.2012.283. Epub 2012 Dec 11.
To measure the frequency of estrogen receptor (ER), progesterone receptor (PR), and Her 2 Neu positivity and to study their association with tumour characteristics and menopausal status in a breast cancer cohort from Northern Pakistan.
Patients attending NORI with histopathologically proven diagnosis of invasive ductal carcinoma of the breast were included after providing informed consent. Age, menopausal status, and tumour size were recorded. The presence or absence of nodal involvement (including site and number), distant metastases, sites of metastases, skin involvement, chest wall involvement, recurrent disease, and bilateral breast cancer were noted along with ER, PR, and Her 2 Neu status. Mean ± standard deviations were calculated for continuous variables like age. Frequency and percentage were calculated for categorical variables like ER, PR, and Her 2 Neu status. Association of ER, PR, and Her 2 Neu status with menopausal status and tumour-related characteristics were sought employing t test, x(2 )square test, and ANOVA wherever appropriate. P value >0.05 was considered significant.
There were 1226 patients included in the study. Mean patient age was 48.04 ± 11.97 years, and 743 (60.6%) patients were premenopausal. ER, PR, and Her 2 Neu were found positive in 763 (62.2%), 738 (60.1%), and 478 (38.9%) patients, respectively. Significant association (P < 0.05) was found between ER, PR positivity, and Her 2 Neu over expression with menopausal status, tumour size, involvement of skin, chest wall and lymph nodes and the presence of distant metastases. However, no significant association was detected between ER, PR, Her 2 Neu and recurrent disease.
The frequency of expression of hormonal receptors in breast cancer patients from Northern Pakistan is the same as reported in the literature although overexpression of Her 2 Neu is a little higher in our population. There is an inverse relationship between hormonal receptors expression and Her 2 Neu expression. Postmenopausal women have a higher incidence of ER and PR positivity and Her 2 Neu negativity. ER and PR negativity and Her 2 Neu positivity are associated with more advanced disease and poor outcome.
测定巴基斯坦北部乳腺癌队列中雌激素受体（ER）、孕激素受体（PR）及人表皮生长因子受体2（Her 2 Neu）阳性的频率，并研究它们与肿瘤特征及绝经状态的相关性。
纳入在努尔癌症研究所就诊、经组织病理学确诊为乳腺浸润性导管癌且签署知情同意书的患者。记录年龄、绝经状态及肿瘤大小。记录有无淋巴结受累（包括部位及数量）、远处转移、转移部位、皮肤受累、胸壁受累、复发性疾病及双侧乳腺癌情况，同时记录ER、PR及Her 2 Neu状态。对年龄等连续变量计算均值±标准差，对ER、PR及Her 2 Neu状态等分类变量计算频率及百分比。根据情况采用t检验、卡方检验及方差分析来探寻ER、PR及Her 2 Neu状态与绝经状态及肿瘤相关特征的相关性。P值>0.05被视为具有显著性。
本研究共纳入1226例患者。患者平均年龄为48.04±11.97岁，743例（60.6%）患者为绝经前。ER、PR及Her 2 Neu分别在763例（62.2%）、738例（60.1%）及478例（38.9%）患者中呈阳性。发现ER、PR阳性及Her 2 Neu过表达与绝经状态、肿瘤大小、皮肤受累、胸壁受累、淋巴结受累及远处转移的存在之间存在显著相关性（P<0.05）。然而，未检测到ER、PR、Her 2 Neu与复发性疾病之间存在显著相关性。
巴基斯坦北部乳腺癌患者中激素受体的表达频率与文献报道相同，尽管我们人群中Her 2 Neu的过表达略高。激素受体表达与Her 2 Neu表达呈负相关。绝经后女性ER和PR阳性及Her 2 Neu阴性的发生率更高。ER和PR阴性及Her 2 Neu阳性与更晚期疾病及不良预后相关。
