Chauhan Richa, Trivedi Vinita, Rani Rita, Singh Usha
Department of Radiotherapy, Mahavir Cancer Sansthan, Patna, Bihar, India.
J Midlife Health. 2020 Oct-Dec;11(4):210-216. doi: 10.4103/jmh.JMH_97_20. Epub 2021 Jan 21.
Breast cancer is now the most common cancer among Indian women. Recent studies have suggested a possible link between risk factors like high BMI and molecular subtypes of breast cancer. Studies from Western and Asian population have shown varying relationship between post- menopausal obesity and expression of ER, PR, Her2-neu receptors in breast cancer patients.
This study was done with an aim to explore if overweight or obesity as defined by BMI and status of ER, PR and Her2-neu receptors differ in Indian pre-menopausal and post-menopausal breast cancer patients.
This is a retrospective analysis of 446 breast cancer patients treated at Mahavir Cancer Sansthan, Patna from July to December 2019. Their case records were evaluated and data regarding age, menopausal status, height, weight and ER, PR & HER2-neu receptor status were extracted for analyses.
Chi-square test was used to compare categorical variables between the pre-menopausal and post-menopausal group.
The prevalence of obesity in the post-menopausal group was 2.3% more than the pre-menopausal group (-value = 0.24). As compared to the pre-menopausal group, there was an increase in the ER/PR positivity in the postmenopausal group by 3.41% (-value = 0.47) and in the Her2-neu positivity by 6.38% (-value = 0.15). As compared to the pre-menopausal group, there was further increase in the ER/PR positivity in the post-menopausal group by 6.85% (-value = 0.40) in sub-group of patients with BMI ≥ 25kg/m.
Our study showed slightly increased incidence of obesity in post-menopausal breast cancer patients. Overweight post-menopausal patients also had a higher percentage of ER/PR receptor positivity and lower percentage of Triple negative breast cancer. The percentage of Her2-neu receptor positivity was more in post-menopausal patients. A high BMI was found to be associated with a lower Her2neu positivity.
乳腺癌目前是印度女性中最常见的癌症。最近的研究表明，高体重指数等风险因素与乳腺癌的分子亚型之间可能存在联系。来自西方和亚洲人群的研究显示，绝经后肥胖与乳腺癌患者雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（Her2-neu）受体表达之间的关系各不相同。
本研究旨在探讨根据体重指数定义的超重或肥胖以及ER、PR和Her2-neu受体状态在印度绝经前和绝经后乳腺癌患者中是否存在差异。
这是一项对2019年7月至12月在巴特那的玛哈维尔癌症中心接受治疗的446例乳腺癌患者的回顾性分析。评估他们的病例记录，并提取有关年龄、绝经状态、身高、体重以及ER、PR和HER2-neu受体状态的数据进行分析。
采用卡方检验比较绝经前和绝经后组之间的分类变量。
绝经后组的肥胖患病率比绝经前组高2.3%（P值=0.24）。与绝经前组相比，绝经后组的ER/PR阳性率增加了3.41%（P值=0.47），Her2-neu阳性率增加了6.38%（P值=0.15）。在体重指数≥25kg/m²的患者亚组中，与绝经前组相比，绝经后组的ER/PR阳性率进一步增加了6.85%（P值=0.40）。
我们的研究表明，绝经后乳腺癌患者的肥胖发病率略有增加。超重的绝经后患者ER/PR受体阳性率也较高，三阴性乳腺癌的比例较低。绝经后患者中Her2-neu受体阳性率更高。发现高体重指数与较低的Her2-neu阳性率相关。
