Jha Arun Kumar, Chadha Sanjim, Bhalla Preena, Saini Sanjeev
Department of Microbiology, Maulana Azad Medical College, University of Delhi, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Hepat Res Treat. 2012;2012:520362. doi: 10.1155/2012/520362. Epub 2012 Dec 4.
The risk of contracting HBV by health care workers (HCW) is four-times greater than that of general adult population. Studies have demonstrated that vaccine-induced protection persists at least 11 years. High risk groups such as HCWs should be monitored and receive a booster vaccination if their anti-HBsAb levels decrease below 10 mIU/mL. In view of the above this study was undertaken to assess the HBV vaccination of the HCWs and their immunological response. Seventy-two HCWs of the Department of Microbiology, Maulana Azad Medical College, New Delhi, India, were recruited and blood sample was drawn for serological tests (HBSAg, anti-HCV, anti-HBsAb, anti-HBeAb, and anti-HBcAb). Anti-HBs titers of >10 mIU/mL were considered protective. Thirty-four (47.3%) of the participants were completely vaccinated with three doses. 25 (73.5%) of the participants with complete vaccination had protective anti-HBsAb levels as against 8 (53.3%) of those with incomplete vaccination and 9 (39.1%) of those who were not vaccinated at all. One of our participants was acutely infected while 29 participants were susceptible to infection at the time of the study. All HCWs should receive three doses of the vaccine and be monitored for their immune status after every five years. Boosters should be administered to those who become susceptible.
医护人员感染乙肝病毒（HBV）的风险是普通成年人群的四倍。研究表明，疫苗诱导的保护作用至少持续11年。像医护人员这样的高风险群体应接受监测，如果其抗-HBsAb水平降至10 mIU/mL以下，应接受加强疫苗接种。鉴于上述情况，本研究旨在评估医护人员的乙肝疫苗接种情况及其免疫反应。印度新德里穆拉纳·阿扎德医学院微生物学系的72名医护人员被招募，并采集血样进行血清学检测（HBsAg、抗-HCV、抗-HBsAb、抗-HBeAb和抗-HBcAb）。抗-HBs滴度>10 mIU/mL被认为具有保护作用。34名（47.3%）参与者完成了三剂疫苗的全程接种。完成接种的参与者中有25名（73.5%）具有保护性抗-HBsAb水平，而未完成接种的参与者中有8名（53.3%），完全未接种的参与者中有9名（39.1%）。我们的一名参与者发生了急性感染，而29名参与者在研究时易感染。所有医护人员都应接种三剂疫苗，并每五年监测一次免疫状态。应对那些易感染的人员进行加强接种。
