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脂肪间充质干细胞。其特征及在组织修复中的潜在应用。

Adipose mesenchymal stem cells. Their characteristics and potential application in tissue repair.

作者信息

Włodarski Krzysztof H, Włodarski Paweł, Galus Ryszard, Mazur Sławomir

机构信息

Department of Histology and Embryology Biostructure Center, Medical University of Warsaw, Warsaw, Poland.

出版信息

Pol Orthop Traumatol. 2012 Dec 15;77:97-9.

PMID:23306294
Abstract

Mesenchymal stem cells, derived from adipose tissue do not differ substantially from mesenchymal stem cells isolated from bone marrow stroma. They are able to differentiate in differentiating culture medium into various cell type of mesodermal lineage, but also into cells of ectodermal type. Their potency to differentiate toward osteogenic and adipogenic lineage is promising to be a ready source of cells for tissue regeneration.

摘要

源自脂肪组织的间充质干细胞与从骨髓基质中分离出的间充质干细胞并无本质区别。它们能够在分化培养基中分化为中胚层谱系的各种细胞类型,也能分化为外胚层类型的细胞。它们向成骨和成脂谱系分化的能力有望成为组织再生的现成细胞来源。

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Cell Transplant. 2020 Jan-Dec;29:963689720917341. doi: 10.1177/0963689720917341.
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Delivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro model.在体外模型中,Sox9基因的递送可促进人脐带血来源间充质干细胞的软骨形成分化。
Braz J Med Biol Res. 2014 Apr;47(4):279-86. doi: 10.1590/1414-431X20133539. Epub 2014 Mar 18.