一种新型乙型肝炎疫苗含有 AdvaxTM，一种来源于德尔塔菊粉的多糖佐剂，在临床前研究中具有良好的体液和细胞免疫原性，且具有最小的反应原性。
A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing.
机构信息
Vaxine Pty Ltd., Bedford Park, Adelaide 5042, Australia.
出版信息
Vaccine. 2013 Apr 8;31(15):1999-2007. doi: 10.1016/j.vaccine.2012.12.077. Epub 2013 Jan 7.
Abstract
Although current HBV vaccines have an outstanding record of safety and efficacy, reduced immunogenicity is a problem in those of older age, or having renal impairment or diabetes mellitus. In this study, we tested the ability of Advax™ adjuvant, a novel polysaccharide adjuvant based on delta inulin, to enhance the immunogenicity of hepatitis B surface antigen (HBs) in mice and guinea pigs by comparison to the traditional alum adjuvant. Advax™ provided antigen-sparing, significantly enhanced both anti-HBs antibody titers, and anti-HBs CD4 and CD8 T-cells, with increases in Th1, Th2 and Th17 cytokine responses. Unlike alum, the adjuvant effect of Advax™ was seen even when injected 24h before the HBs antigen. Advax™ adjuvant similarly enhanced humoral and cellular immune responses in guinea pigs to a third generation preS-HBs antigen. Advax™ adjuvant when combined with HBs antigen could provide enhanced protection over current generation HBV vaccines for immunization of low responder populations.
摘要
尽管目前的乙型肝炎病毒疫苗具有出色的安全性和功效记录，但在年龄较大、肾功能不全或患有糖尿病的人群中，其免疫原性会降低。在这项研究中，我们通过与传统的明矾佐剂相比，测试了 Advax™佐剂（一种基于德尔塔菊粉的新型多糖佐剂）增强乙型肝炎表面抗原（HBs）在小鼠和豚鼠中的免疫原性的能力。Advax™提供了抗原节省，显著增强了抗-HBs 抗体滴度和抗-HBs CD4 和 CD8 T 细胞，增加了 Th1、Th2 和 Th17 细胞因子反应。与明矾不同的是，即使在注射 HBs 抗原前 24 小时注射，Advax™佐剂也能发挥佐剂作用。Advax™佐剂同样增强了豚鼠对第三代前 S-HBs 抗原的体液和细胞免疫反应。Advax™佐剂与 HBs 抗原结合使用时，可为免疫应答较低的人群提供比现有乙型肝炎病毒疫苗更好的保护作用。
相似文献
1
A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing.一种新型乙型肝炎疫苗含有 AdvaxTM，一种来源于德尔塔菊粉的多糖佐剂，在临床前研究中具有良好的体液和细胞免疫原性，且具有最小的反应原性。
Vaccine. 2013 Apr 8;31(15):1999-2007. doi: 10.1016/j.vaccine.2012.12.077. Epub 2013 Jan 7.
2
Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses.Advax™ 是一种源自菊糖 delta 的多糖佐剂，通过广泛增强适应性免疫反应，提供了更好的流感疫苗保护效果。
Vaccine. 2012 Aug 3;30(36):5373-81. doi: 10.1016/j.vaccine.2012.06.021. Epub 2012 Jun 20.
3
Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: a randomized controlled Phase 1 study.基于δ-菊粉的新型多糖佐剂Advax™与乙型肝炎表面抗原联合制剂的免疫原性和安全性：一项随机对照1期研究
Vaccine. 2014 Nov 12;32(48):6469-77. doi: 10.1016/j.vaccine.2014.09.034. Epub 2014 Sep 27.
4
A gold glyco-nanoparticle carrying a Listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection.携带李斯特菌溶血素O肽并与Advax™δ-菊粉佐剂配制的金糖纳米颗粒可诱导强大的T细胞保护作用，抵御李斯特菌感染。
Vaccine. 2015 Mar 17;33(12):1465-73. doi: 10.1016/j.vaccine.2015.01.062. Epub 2015 Feb 7.
5
Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety.Advax™是一种由δ-菊粉工程化制备的新型微晶多糖颗粒，具有强大的佐剂效力以及耐受性和安全性。
Vaccine. 2015 Nov 4;33(44):5920-6. doi: 10.1016/j.vaccine.2015.09.030. Epub 2015 Sep 25.
6
Posintro™-HBsAg, a modified ISCOM including HBsAg, induces strong cellular and humoral responses.Posintro™-HBsAg，一种包含 HBsAg 的改良 ISCOM，可诱导强烈的细胞和体液免疫反应。
Int J Pharm. 2011 Jul 29;414(1-2):312-20. doi: 10.1016/j.ijpharm.2011.05.026. Epub 2011 May 12.
7
The new nano-complex, Hep-c, improves the immunogenicity of the hepatitis B vaccine.新型纳米复合物 Hep-c 可提高乙肝疫苗的免疫原性。
Vaccine. 2013 May 24;31(22):2591-7. doi: 10.1016/j.vaccine.2013.03.030. Epub 2013 Apr 10.
8
Polycation-decorated PLA microspheres induce robust immune responses via commonly used parenteral administration routes.聚阳离子修饰的聚乳酸微球通过常用的肠胃外给药途径诱导强烈的免疫反应。
Int Immunopharmacol. 2014 Dec;23(2):592-602. doi: 10.1016/j.intimp.2014.10.010.
9
Humoral immune responses in mice using gamma inulin preparations as adjuvants for hepatitis B vaccines.使用γ-菊粉制剂作为乙肝疫苗佐剂时小鼠的体液免疫反应。
Immunol Cell Biol. 1990 Apr;68 ( Pt 2):107-12. doi: 10.1038/icb.1990.15.
10
Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination against hepatitis B by using a third generation PreS/S vaccine.使用第三代前S/S疫苗在对传统乙肝疫苗无反应和低反应者中诱导强大的T细胞和B细胞免疫反应。
Vaccine. 2014 Sep 3;32(39):5077-82. doi: 10.1016/j.vaccine.2014.06.076. Epub 2014 Jun 24.
引用本文的文献
1
One Health adjuvant selection for vaccines against zoonotic infections.针对人畜共患病感染疫苗的“同一健康”佐剂选择
Explor Med. 2025;6. doi: 10.37349/emed.2025.1001316. Epub 2025 May 7.
2
Progress and prospect of polysaccharides as adjuvants in vaccine development.多糖作为疫苗佐剂在疫苗开发中的进展与前景
Virulence. 2024 Dec;15(1):2435373. doi: 10.1080/21505594.2024.2435373. Epub 2024 Dec 5.
3
Simplified scalable synthesis of a water-soluble toll-like receptor 2 agonistic lipopeptide adjuvant for use with protein-based viral vaccines.用于基于蛋白质的病毒疫苗的水溶性Toll样受体2激动剂脂肽佐剂的简化可扩展合成。
Bioorg Chem. 2024 Dec;153:107835. doi: 10.1016/j.bioorg.2024.107835. Epub 2024 Sep 22.
4
Overview of Hepatitis B Vaccine Non-Response and Associated B Cell Amnesia: A Scoping Review.乙肝疫苗无应答及相关B细胞记忆缺失概述：一项范围综述
Pathogens. 2024 Jul 2;13(7):554. doi: 10.3390/pathogens13070554.
5
Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines.Advax-SM™佐剂COBRA（H1/H3）血凝素流感疫苗。
Vaccines (Basel). 2024 Apr 24;12(5):455. doi: 10.3390/vaccines12050455.
6
Lung IL-17A-Producing CD4 T Cells Correlate with Protection after Intrapulmonary Vaccination with Differentially Adjuvanted Tuberculosis Vaccines.肺内产生白细胞介素-17A的CD4 T细胞与不同佐剂结核疫苗肺内接种后的保护作用相关。
Vaccines (Basel). 2024 Jan 26;12(2):128. doi: 10.3390/vaccines12020128.
7
Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to in Mice and Non-Human Primates.佐剂融合蛋白疫苗在小鼠和非人灵长类动物中诱导对……的持久免疫力。 （原文中“to”后面内容缺失）
Vaccines (Basel). 2023 Jul 6;11(7):1212. doi: 10.3390/vaccines11071212.
8
Nano selenium-enriched probiotic enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity.纳米硒富益生菌增强明矾佐剂作用并促进抗原特异性全身和黏膜免疫。
Front Immunol. 2023 Jan 27;14:1116223. doi: 10.3389/fimmu.2023.1116223. eCollection 2023.
9
Prior respiratory syncytial virus infection reduces vaccine-mediated Th2-skewed immunity, but retains enhanced RSV F-specific CD8 T cell responses elicited by a Th1-skewing vaccine formulation.先前的呼吸道合胞病毒感染会降低疫苗介导的 Th2 偏向性免疫，但保留了 Th1 偏向性疫苗制剂引发的增强的 RSV F 特异性 CD8 T 细胞反应。
Front Immunol. 2022 Oct 4;13:1025341. doi: 10.3389/fimmu.2022.1025341. eCollection 2022.
10
Biomedical nanomaterials for immunological applications: ongoing research and clinical trials.用于免疫应用的生物医学纳米材料：正在进行的研究和临床试验。
Nanoscale Adv. 2020 Aug 24;2(11):5046-5089. doi: 10.1039/d0na00478b. eCollection 2020 Nov 11.
本文引用的文献
1
Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses.Advax™ 是一种源自菊糖 delta 的多糖佐剂，通过广泛增强适应性免疫反应，提供了更好的流感疫苗保护效果。
Vaccine. 2012 Aug 3;30(36):5373-81. doi: 10.1016/j.vaccine.2012.06.021. Epub 2012 Jun 20.
2
Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant.随机临床试验免疫原性和安全性的一种重组 H1N1/2009 大流行性流感疫苗含有 Advax™多糖佐剂。
Vaccine. 2012 Aug 3;30(36):5407-16. doi: 10.1016/j.vaccine.2012.06.009. Epub 2012 Jun 17.
3
Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age.在 18-55 岁健康成年人中，比较两种剂量的研究用乙型肝炎病毒表面抗原与免疫刺激性硫代磷酸寡脱氧核苷酸联合使用，以及三种剂量的已上市乙型肝炎疫苗的安全性和免疫原性。
Vaccine. 2012 Mar 28;30(15):2556-63. doi: 10.1016/j.vaccine.2012.01.087. Epub 2012 Feb 9.
4
Hepatitis B virus vaccine in chronic kidney disease: improved immunogenicity by adjuvants? A meta-analysis of randomized trials.乙型肝炎病毒疫苗在慢性肾脏病中的应用：佐剂是否可提高其免疫原性？一项随机试验的荟萃分析。
Vaccine. 2012 Mar 16;30(13):2295-300. doi: 10.1016/j.vaccine.2012.01.064. Epub 2012 Jan 26.
5
Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults ≥50 years.改良工艺乙肝疫苗在≥50岁健康成年人中的安全性和免疫原性。
Hum Vaccin. 2011 Dec;7(12):1336-42. doi: 10.4161/hv.7.12.18333. Epub 2011 Dec 1.
6
Evaluation of hepatitis B vaccine immunogenicity among older adults during an outbreak response in assisted living facilities.在辅助生活设施中暴发应对期间评估老年人的乙型肝炎疫苗免疫原性。
Vaccine. 2011 Nov 21;29(50):9316-20. doi: 10.1016/j.vaccine.2011.10.011. Epub 2011 Oct 18.
7
Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets.Delta 菊糖多聚糖佐剂增强了裂解病毒 H5N1 疫苗对雪貂致命性攻击的保护能力。
Vaccine. 2011 Aug 26;29(37):6242-51. doi: 10.1016/j.vaccine.2011.06.078. Epub 2011 Jul 6.
8
Vaccine production, distribution, access, and uptake.疫苗生产、分发、可及性和接种。
Lancet. 2011 Jul 30;378(9789):428-38. doi: 10.1016/S0140-6736(11)60478-9. Epub 2011 Jun 12.
9
Programming the magnitude and persistence of antibody responses with innate immunity.用先天免疫来编程抗体反应的强度和持久性。
Nature. 2011 Feb 24;470(7335):543-7. doi: 10.1038/nature09737.
10
A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development.霍乱毒素 A1-DD 佐剂的独特作用：促进长期血浆细胞和记忆 B 细胞的发育。
J Immunol. 2011 Feb 1;186(3):1399-410. doi: 10.4049/jimmunol.1002881. Epub 2011 Jan 3.
Zotero 插件