Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Biol Trace Elem Res. 2013 Apr;152(1):75-81. doi: 10.1007/s12011-013-9598-7. Epub 2013 Jan 11.
Acrylamide is an organic chemical which occurs in foods widespreadly consumed in diets worldwide. The purpose of this study was to evaluate the serum trace element levels (Fe, Cu, Zn, Mn, Cr, Se, Co, Ni, V, As, Mg, P, Li, K, Al) in Wistar rats exposed to acrylamide. Acrylamide was administered to the treatment groups at 2 and 5 mg/kg body weight (bw)/day via drinking water for 90 days. Inductively coupled plasma mass spectrometry was used for the determination of serum trace element concentrations. Serum Zn, Se, Co, V and Mg concentrations of 5 mg/kg bw/day acrylamide-treated male rats were lower, whereas serum As concentration was higher than the same parameters of the controls rats. Similarly, serum Zn, Se, Co, V and Mg concentrations were decreased in 5 mg/kg bw/day acrylamide-treated female rats compared with control rats. On the other hand, there were no significant differences between serum Fe, Cu, Mn, Cr, Ni, P, Li, K and Al concentrations of all groups. The results from this study provide evidence that dietary acrylamide intake adversely affects the serum trace elements status.
丙烯酰胺是一种有机化学物质，广泛存在于世界各地饮食中广泛消费的食品中。本研究的目的是评估接触丙烯酰胺的 Wistar 大鼠的血清微量元素水平（Fe、Cu、Zn、Mn、Cr、Se、Co、Ni、V、As、Mg、P、Li、K、Al）。丙烯酰胺以 2 和 5mg/kg 体重（bw）/天的剂量通过饮用水给予处理组，持续 90 天。电感耦合等离子体质谱法用于测定血清微量元素浓度。5mg/kg bw/day 丙烯酰胺处理的雄性大鼠的血清 Zn、Se、Co、V 和 Mg 浓度较低，而血清 As 浓度高于对照组大鼠的相同参数。同样，与对照组大鼠相比，5mg/kg bw/day 丙烯酰胺处理的雌性大鼠的血清 Zn、Se、Co、V 和 Mg 浓度也降低了。另一方面，所有组的血清 Fe、Cu、Mn、Cr、Ni、P、Li、K 和 Al 浓度之间没有显著差异。本研究的结果提供了证据，表明膳食丙烯酰胺摄入会对血清微量元素状况产生不利影响。
