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[心得安与α-生育酚在稳定型劳力性心绞痛患者中的应用]

[The use of finoptin and alpha-tocopherol in patients with stable exertional stenocardia].

作者信息

Levchenko V A, Serediuk N N, Gereliuk I P, Vakaliuk I P, Bondar' M M

出版信息

Vrach Delo. 1990 Jan(1):61-4.

PMID:2330715
Abstract

A study of 59 patients of stable exertion stenocardia (functional class III) revealed an increased content of lipid hydroperoxide in lipoproteids of low and very low density that was associated with an increased level of malonic dialdehyde in of their functional activity, in particular, during physical loads. Finoptin monotherapy did not effect essentially the level of hydroperoxides in lipoproteids of low density, malonic dialdehyde in thrombocytes. Combination of finoptin and alpha-tocopherol reduced essentially the processes of lipid peroxidation, reducing, thus, the functional activity of thrombocytes at rest and loads.

摘要

一项针对59例稳定型劳力性心绞痛(功能分级为III级)患者的研究表明,低密度和极低密度脂蛋白中的脂质过氧化氢含量增加,这与丙二醛水平升高有关,尤其是在体力负荷期间其功能活性增强。单用芬多精对低密度脂蛋白中的过氧化氢水平、血小板中的丙二醛水平基本没有影响。芬多精与α-生育酚联合使用可显著减少脂质过氧化过程,从而降低血小板在静息和负荷状态下的功能活性。

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