Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA.
Curr Atheroscler Rep. 2012 Oct;14(5):450-9. doi: 10.1007/s11883-012-0274-8.
Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 C(high/low)) and humans (CD14(+/dim/-) CD16(+/-)) in the context of atherosclerosis and its complications.
单核细胞通常被描述为巨噬细胞的骨髓前体细胞。尽管许多研究支持这种观点，但我们现在认识到单核细胞既不是仅在骨髓中发育的，也不是所有巨噬细胞和树突状细胞的来源。除了分化为特定的白细胞群外，单核细胞作为单核细胞在功能和个体发生上是异质的。在这篇综述中，我们将重点关注在动脉粥样硬化及其并发症的背景下，小鼠（Ly-6C（高/低））和人类（CD14（+/dim/-）CD16（+/-））中单核细胞及其亚群的发育和活性。
