Del Pero R A, Gigstad J E, Roberts A D, Klintworth G K, Martin C A, L'Esperance F A, Taylor D M
University of Connecticut Health Center, Farmington.
Am J Ophthalmol. 1990 Apr 15;109(4):419-29. doi: 10.1016/s0002-9394(14)74608-2.
Using a 193-nm excimer laser, we produced wide-area, refractive keratectomies on 18 cynomolgus monkey corneas and followed them up for up to 18 months. All corneas developed some subepithelial haze by one month. Electron microscopy disclosed epithelial thickening, absence of Bowman's layer, and subepithelial activated fibroblasts surrounded by disorganized collagen. By six months, the haze faded to a variable degree, the epithelium regained normal thickness, and the collagen was more organized. Persistent corneal haze at 12 months in some corneas correlated with electronlucent spaces in the subepithelial zone. Corneas were 90 microns thinner centrally two weeks after myopic ablation, but returned to preoperative thickness by six months. Myopic flattening and hyperopic steepening of 6 diopters were targeted, and over 7 diopters of each were achieved initially. Regression of induced curvature stabilized over several months. At 18 months, 4.4 diopters of myopic flattening and 5.2 diopters of hyperopic steepening remained.
我们使用193纳米准分子激光，在18只食蟹猴的角膜上进行了大面积的屈光性角膜切除术，并对其进行了长达18个月的随访。到1个月时，所有角膜均出现了一些上皮下混浊。电子显微镜检查显示上皮增厚、Bowman层缺失以及上皮下活化的成纤维细胞被杂乱的胶原纤维包围。到6个月时，混浊程度不同程度减轻，上皮恢复正常厚度，胶原纤维排列更有序。一些角膜在12个月时持续存在的角膜混浊与上皮下区域的电子透亮间隙有关。近视性消融术后两周，角膜中央变薄90微米，但在6个月时恢复到术前厚度。目标是近视性变平6屈光度和远视性变陡6屈光度，最初均实现了超过7屈光度的变化。诱导曲率的回退在几个月内稳定下来。到18个月时，仍保留4.4屈光度的近视性变平和5.2屈光度的远视性变陡。
