Birlouez-Aragon I, Alloussi S
Laboratoire de Nutrition Humaine, Institut National Agronomique Paris-Grignon, Thiverval-Grignon, France.
Ann Nutr Metab. 1990;34(1):1-7. doi: 10.1159/000177563.
This study was carried out on two groups of healthy young subjects. One group (n = 8) was given a single oral dose of galactose (0.5 g/kg body weight), and a single measurement of blood galactose was made 40 min later. A second group (n = 16) was given a daily supplement of 0.5 g/kg galactose for 15 days, and blood galactose and galactitol were measured. On the first day of the test period, some subjects seemed to tolerate galactose less well than others: galactitol appeared in their plasmas and could be related to a significantly higher galactosaemia than that of subjects without detectable galactitol in the plasma. However, after 15 days of galactose intake, the less galactose-tolerant subjects appeared to have adapted, as indicated by the significant decrease in the blood galactose and the disappearance of galactitol. No change was found in the galactose-tolerant subjects. No significant difference was found between males and females.
本研究针对两组健康青年受试者开展。一组（n = 8）口服单剂量半乳糖（0.5 g/kg体重），40分钟后单次测量血半乳糖。另一组（n = 16）连续15天每日补充0.5 g/kg半乳糖，并测量血半乳糖和半乳糖醇。在试验期的第一天，一些受试者对半乳糖的耐受性似乎不如其他受试者：他们的血浆中出现了半乳糖醇，且与血浆中未检测到半乳糖醇的受试者相比，半乳糖血症显著更高。然而，摄入半乳糖15天后，对半乳糖耐受性较差的受试者似乎已经适应，表现为血半乳糖显著下降和半乳糖醇消失。对半乳糖耐受性良好的受试者未发现变化。男性和女性之间未发现显著差异。
