东亚人群中TCF7L2基因单核苷酸多态性与2型糖尿病关联的荟萃分析。
Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
作者信息
Luo Yingying, Wang Hongyuan, Han Xueyao, Ren Qian, Wang Fang, Zhang Xiuying, Sun Xiuqin, Zhou Xianghai, Ji Linong
机构信息
Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, PR China.
出版信息
Diabetes Res Clin Pract. 2009 Aug;85(2):139-46. doi: 10.1016/j.diabres.2009.04.024. Epub 2009 May 30.
AIMS
To evaluate the effect of TCF7L2 on genetic susceptibility of type 2 diabetes (T2DM) in East Asian population by using the meta-analysis.
METHODS
Search all the publications about the association between TCF7L2 and T2DM in East Asian population from PubMed, CNKI and abstracts of major diabetes conferences. Perform the meta-analysis of all the validated studies and evaluate the association between rs7903146 T allele, rs12255372 T allele, rs11196205 C allele, rs290487 C allele and rs11196218 G allele of TCF7L2 and the risk of T2DM.
RESULTS
Eleven studies from nine eligible papers and one unpublished study of ours were included in the meta-analysis. Ten eligible studies were analyzed for rs7903146, five were analyzed for rs12255372 and rs11196205, and three were analyzed for rs290487 and rs11196218. We found that four SNPs (rs7903146, rs12255372, rs11196205, rs290487) in TCF7L2 were significantly associated with T2DM in East Asian populations. The rs11196218 also showed a marginal association. The estimated population-attributable risk (PAR) associated with analyzed SNPs ranged from 2% to 7%.
CONCLUSIONS
SNPs in TCF7L2 were strongly associated with the risk of T2DM in East Asian population. But the contribution of its genetic variants to the epidemic of type 2 diabetes in East Asian was relatively low.
目的
通过荟萃分析评估TCF7L2对东亚人群2型糖尿病（T2DM）遗传易感性的影响。
方法
从PubMed、中国知网以及主要糖尿病会议的摘要中检索所有关于东亚人群中TCF7L2与T2DM关联的出版物。对所有经过验证的研究进行荟萃分析，并评估TCF7L2的rs7903146 T等位基因、rs12255372 T等位基因、rs11196205 C等位基因、rs290487 C等位基因和rs11196218 G等位基因与T2DM风险之间的关联。
结果
荟萃分析纳入了来自9篇合格论文的11项研究以及我们一项未发表的研究。对rs7903146进行分析的有10项合格研究，对rs12255372和rs11196205进行分析的有5项，对rs290487和rs11196218进行分析的有3项。我们发现TCF7L2中的4个单核苷酸多态性（SNPs，即rs7903146、rs12255372、rs11196205、rs290487）与东亚人群的T2DM显著相关。rs11196218也显示出边缘关联。与分析的SNPs相关的估计人群归因风险（PAR）范围为2%至7%。
结论
TCF7L2中的SNPs与东亚人群的T2DM风险密切相关。但其基因变异对东亚2型糖尿病流行的贡献相对较低。
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