生殖、脂肪代谢和寿命：它们之间有什么联系？
Reproduction, fat metabolism, and life span: what is the connection?
机构信息
Sanford-Burnham Medical Research Institute, Del E. Webb Neuroscience, Aging and Stem Cell Research Center, Development and Aging Program, La Jolla, CA 92037, USA.
出版信息
Cell Metab. 2013 Jan 8;17(1):10-9. doi: 10.1016/j.cmet.2012.12.003.
Abstract
Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germline removal in the nematode Caenorhabditis elegans promotes longevity in part by modulating lipid metabolism through effects on fatty acid desaturation, lipolysis, and autophagy. Here, we review these recent studies and discuss the mechanisms by which reproduction modulates fat metabolism and life span. Elucidating the relationship between these processes could contribute to our understanding of age-related diseases including metabolic disorders.
摘要
在多种生物中，繁殖能力的降低与脂肪储存的增加和寿命的延长有关，但潜在的调节机制仍知之甚少。最近在多个物种中的研究提供了证据，表明繁殖、脂肪代谢和寿命直接相关。例如，线虫秀丽隐杆线虫的生殖系去除部分通过影响脂肪酸去饱和、脂肪分解和自噬来调节脂肪代谢，从而促进长寿。在这里，我们回顾了这些最近的研究，并讨论了繁殖调节脂肪代谢和寿命的机制。阐明这些过程之间的关系有助于我们理解包括代谢紊乱在内的与年龄相关的疾病。
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