内源性 CETP 活性作为心血管风险的预测因子：最佳范围的确定。
Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range.
机构信息
INSERM UMRS939, Hôpital de la Pitié, Paris, France.
出版信息
Atherosclerosis. 2013 Mar;227(1):165-71. doi: 10.1016/j.atherosclerosis.2012.12.024. Epub 2013 Jan 2.
OBJECTIVES
To identify key determinants of plasma endogenous CETP activity and threshold value of plasma CETP activity associated with high cardiovascular risk.
METHODS
Endogenous plasma CETP activity was measured in a total of 1403 individuals.
RESULTS
Multivariate analysis revealed that 23.5% of endogenous CETP activity variability was explained by plasma LDL-C (12.0%), HDL-C (6.4%) and TG (4.4%) whereas sex and BMI accounted together for only 0.7% of its variability. Scoring patients for cardiovascular risk on the basis of their plasma lipid levels (TC, TG, LDL-C and HDL-C), revealed that patients with high cardiovascular risk (score ≥3) displayed a mean endogenous plasma CETP activity above 34%.
CONCLUSION
Plasma CETP activity represents a potent indicator of cardiovascular risk in patients with metabolic disorders since it integrates major independent risk factors.
目的
确定与高心血管风险相关的血浆内源性 CETP 活性的关键决定因素和血浆 CETP 活性的阈值。
方法
共测量了 1403 个人的内源性血浆 CETP 活性。
结果
多元分析显示，血浆 LDL-C（12.0%）、HDL-C（6.4%）和 TG（4.4%）解释了内源性 CETP 活性变异性的 23.5%，而性别和 BMI 仅共同解释了其变异性的 0.7%。根据患者的血浆脂质水平（TC、TG、LDL-C 和 HDL-C）对心血管风险进行评分，结果显示，心血管风险高的患者（评分≥3）的平均内源性血浆 CETP 活性高于 34%。
结论
由于内源性血浆 CETP 活性综合了主要的独立危险因素，因此它是代谢紊乱患者心血管风险的有力指标。
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