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500 例机器人全内镜冠状动脉旁路移植术:成功率和安全性的预测因素。

Five hundred cases of robotic totally endoscopic coronary artery bypass grafting: predictors of success and safety.

机构信息

Department of Cardiac Surgery, University of Maryland, Baltimore, Maryland; Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria.

出版信息

Ann Thorac Surg. 2013 Mar;95(3):803-12. doi: 10.1016/j.athoracsur.2012.09.071. Epub 2013 Jan 10.

Abstract

BACKGROUND

Robotic technology has enabled totally endoscopic coronary artery bypass (TECAB) grafting. Little information is available on factors associated with successful and safe performance of TECAB. We report a 10-year multicenter experience with 500 cases, elucidating on predictors of success and safety in TECAB procedures.

METHODS

Between 2001 and 2011, 500 patients (364 [73%] men; 136 [27%] women; median age [minimum-maximum] 60 years [31-90 years], median EuroSCORE 2 [0-13]), underwent TECAB. Single, double, triple, and quadruple TECAB was performed in 334, 150, 15, and 1 patient, respectively. Univariate analysis and binary regression models were used to identify predictors of success and safety. Success was defined as freedom from any adverse event and conversion procedure, safety was defined as freedom from major adverse cardiac and cerebral events, major vascular injury, and long-term ventilation.

RESULTS

Success and safety rates were 80% (400 cases) and 95% (474 cases), respectively. Intraoperative conversions to larger thoracic incisions were required in 49 (10%) patients. The median operative time was 305 minutes (112-1,050 minutes), and the mean lengths of stay in the intensive unit (ICU) and in hospital were 23 hours (11-1,048 hours) and 6 days (2-4 days), respectively. Independent predictors of success were single-vessel TECAB (p = 0.004), arrested-heart (AH)-TECAB (p = 0.027), non-learning curve case (p = 0.049), and transthoracic assistance (p = 0.035). The only independent predictor of safety was EuroSCORE (p = 0.002).

CONCLUSIONS

Single-vessel and multivessel TECAB procedures can be safely performed with good reproducible results. Predictors of success include procedure simplicity and non-learning curve cases, whereas predictors of safety are mainly associated with patient selection.

摘要

背景

机器人技术使完全内窥镜冠状动脉旁路移植术(TECAB)成为可能。有关 TECAB 成功和安全实施的相关因素的信息很少。我们报告了一项 10 年的多中心经验,涉及 500 例患者,阐述了 TECAB 手术成功和安全的预测因素。

方法

2001 年至 2011 年,500 例患者(364 例[73%]男性;136 例[27%]女性;中位年龄[最小-最大]60 岁[31-90 岁],中位 EuroSCORE 2[0-13])接受 TECAB 手术。334 例患者行单支、双支、三支和四支 TECAB,150 例、15 例和 1 例患者分别行单支、双支、三支和四支 TECAB。使用单因素分析和二元回归模型来确定手术成功和安全的预测因素。成功定义为无任何不良事件和中转手术,安全定义为无主要心脏和脑不良事件、大血管损伤和长期通气。

结果

手术成功率和安全性分别为 80%(400 例)和 95%(474 例)。49 例(10%)患者术中需要转为较大的胸部切口。中位手术时间为 305 分钟(112-1050 分钟),平均 ICU 和住院时间分别为 23 小时(11-1048 小时)和 6 天(2-4 天)。单支 TECAB(p=0.004)、停跳心脏(AH)-TECAB(p=0.027)、非学习曲线病例(p=0.049)和经胸辅助(p=0.035)是手术成功的独立预测因素。唯一的安全预测因素是 EuroSCORE(p=0.002)。

结论

单支和多支 TECAB 手术可以安全进行,且结果具有良好的可重复性。手术成功的预测因素包括手术简单和非学习曲线病例,而安全的预测因素主要与患者选择有关。

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