HDAC1-mSin3a-NCOR1、Dnmt3b-HDAC1-Egr1 和 Dnmt1-PCNA-UHRF1-G9a 调控 NY-ESO1 基因的表达。
HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression.
机构信息
Centre de Recherche en Cancérologie Nantes-Angers, INSERM U892, Equipe Apoptose et Progression Tumorale, Equipe labellisée Ligue Nationale Contre le Cancer, 8 Quai Moncousu, BP 7021, 44007 Nantes, France.
出版信息
Mol Oncol. 2013 Jun;7(3):452-63. doi: 10.1016/j.molonc.2012.11.004. Epub 2012 Dec 21.
Abstract
The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies. Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated. In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes. Thus, our data illustrate the orchestration of a sequential epigenetic mechanism including the histone deacetylation and methylation, and the DNA methylation processes.
摘要
NY-ESO1 基因是一种癌症/睾丸抗原，被认为是人类恶性肿瘤免疫治疗的合适靶点。尽管已经鉴定出 NY-ESO1 基因在多种肿瘤中的表观遗传沉默，但这一现象涉及的分子机制尚未完全阐明。在两种非上皮性癌症（神经胶质瘤和间皮瘤）中，我们发现 NY-ESO1 基因的表观遗传调控需要 HDAC1-mSin3a-NCOR、Dnmt3b-HDAC1-Egr1 和 Dnmt1-PCNA-UHRF1-G9a 复合物的顺序募集。因此，我们的数据说明了包括组蛋白去乙酰化和甲基化以及 DNA 甲基化过程在内的顺序性表观遗传机制的协调。
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本文引用的文献
1
Histone methylation: a dynamic mark in health, disease and inheritance.组蛋白甲基化：在健康、疾病和遗传中的动态标记。
Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173.
2
Dnmt1/Transcription factor interactions: an alternative mechanism of DNA methylation inheritance.Dnmt1与转录因子的相互作用：DNA甲基化遗传的一种替代机制。
Genes Cancer. 2010 May;1(5):434-43. doi: 10.1177/1947601910373794.
3
Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth.经表观遗传学处理的间皮瘤细胞免疫接种可诱导免疫并阻断肿瘤生长。
Vaccine. 2011 Jul 26;29(33):5534-43. doi: 10.1016/j.vaccine.2011.05.029. Epub 2011 May 25.
4
A 5-aza-2'-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma.5-氮杂-2'-脱氧胞苷/丙戊酸联合诱导针对间皮瘤的细胞毒性 T 细胞反应。
Eur Respir J. 2011 Nov;38(5):1105-16. doi: 10.1183/09031936.00081310. Epub 2011 May 3.
5
Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme.DNA 甲基转移酶表达对多形性胶质母细胞瘤中凋亡相关基因甲基化状态的影响。
Cell Death Dis. 2010;1(1):e8. doi: 10.1038/cddis.2009.7.
6
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.人类 HDAC1 和 HDAC2 在 DNA 损伤反应中发挥作用，促进 DNA 非同源末端连接。
Nat Struct Mol Biol. 2010 Sep;17(9):1144-51. doi: 10.1038/nsmb.1899. Epub 2010 Aug 29.
7
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.组蛋白去乙酰化酶 1（HDAC1），而非 HDAC2，控制胚胎干细胞分化。
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8242-7. doi: 10.1073/pnas.1000478107. Epub 2010 Apr 19.
8
Epigenetic aberrations and therapeutic implications in gliomas.表观遗传学异常与脑胶质瘤的治疗意义
Cancer Sci. 2010 Jun;101(6):1331-6. doi: 10.1111/j.1349-7006.2010.01545.x. Epub 2010 Mar 15.
9
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.DNMT3/转录因子相互作用作为靶向 DNA 甲基化的关键因素。
Epigenetics. 2009 Oct 1;4(7):487-99. doi: 10.4161/epi.4.7.9883. Epub 2009 Oct 21.
10
Immunotherapeutic approaches for glioma.胶质瘤的免疫治疗方法。
Crit Rev Immunol. 2009;29(1):1-42. doi: 10.1615/critrevimmunol.v29.i1.10.
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