Papanikolaou General Hospital, Burn ICU, Hadzipanagiotidi 2, 55236 Thessaloniki, Greece.
Burns. 2013 Jun;39(4):543-8. doi: 10.1016/j.burns.2012.12.009. Epub 2013 Jan 9.
Major burn is often associated with inflammation and coagulation system activation, consumption of endogenous coagulation factors, which have been associated with adverse clinical outcome. Coagulation system dysfunction during early postburn period is characterized by activation of procoagulation pathways, enhanced fibrinolytic activity and impairment of natural anticoagulants activity. Treatment principles focused on the normalization of coagulation and the inhibition of systemic inflammation might have a positive impact on organ function and on the outcome in septic burn patients. Modern treatment strategies using antithrombin, protein C and recombinant factor VIIa are based on early and continuous assessment of the bleeding and coagulation status of burn patients. This allows specific goal directed treatment, thereby optimizing the patient's coagulation status early, minimizing the patient's exposure to blood products, reducing costs and improving the patient's outcome.
大面积烧伤常伴有炎症和凝血系统激活，消耗内源性凝血因子，这与不良临床结局相关。烧伤后早期凝血系统功能障碍的特征是促凝途径激活、纤溶活性增强和天然抗凝剂活性受损。以凝血功能正常化为目标、抑制全身炎症的治疗原则可能对脓毒症烧伤患者的器官功能和结局产生积极影响。使用抗凝血酶、蛋白 C 和重组 VIIa 的现代治疗策略基于对烧伤患者出血和凝血状态的早期和持续评估。这允许进行有针对性的特定治疗，从而尽早优化患者的凝血状态，减少患者对血液制品的暴露，降低成本并改善患者的结局。
