Faculty of Pharmacy, Yunnan University of TCM, Kunming 650500, Yunnan, People's Republic of China.
Fitoterapia. 2013 Mar;85:64-8. doi: 10.1016/j.fitote.2012.12.030. Epub 2013 Jan 10.
Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13μg/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#).
从大翼萼木的叶和嫩枝中分离得到三个新的环阿屯三萜，即 aphagrandinoids A-C（1-3），以及一个新的天然产物 aphagrandinoid D（4）。通过广泛的 NMR 和 MS 技术阐明了它们的结构。Aphagrandinoid A（1）是一个 29-降环阿屯三萜，其侧链具有一个 sprio 环系统，而 aphagrandinoid C（3）是一个五降三萜。还评估了这五个化合物的抗菌活性。化合物 1 和 5 对金黄色葡萄球菌、MRSA 92（#）和 MRSA 98（#）表现出较弱的抗菌活性（MIC 值：1.57-3.13μg/mL）。
