State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Department of Chemical Science and Engineering, Yunnan University, Kunming, P.R. China.
Nat Prod Res. 2022 May;36(10):2473-2478. doi: 10.1080/14786419.2021.1906242. Epub 2021 Jun 8.
Two new cycloartane triterpenoids, (24 )-cycloartane-3,24,25,30-tetrol () and (24 )-24,25,30-trihydroxy-9,19-cycloartane-3-one (), along with three known compounds () were isolated from leaves and twigs of . The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound exhibited cytotoxic activity on all of tested human cancer cell lines, while compound only had specific activity on SMMC-7721 cell line.
从叶子和嫩枝中分离得到两种新的环阿屯三萜类化合物，（24S）-环阿屯-3,24,25,30-四醇（）和（24S）-24,25,30-三羟基-9,19-环阿屯-3-酮（），以及三种已知化合物（）。根据综合光谱分析，包括 1D、2D NMR 和 HREIMS，对新化合物进行了阐明。五种人癌细胞系的体外细胞毒性活性评价表明，化合物对所有测试的人癌细胞系均表现出细胞毒性活性，而化合物仅对 SMMC-7721 细胞系具有特异性活性。
