苦丁茶叶中的三萜类和三萜皂苷。

Triterpenes and triterpenoid saponins from the leaves of Ilex kudincha.

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.

出版信息

Planta Med. 2011 Nov;77(16):1835-40. doi: 10.1055/s-0030-1271164. Epub 2011 Aug 25.

Abstract

One new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A-D (2- 5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectra. Compounds 2, 3, 12, and 13 showed antibacterial activities against Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA).

摘要

从苦丁茶的叶子中分离得到了一种新的三萜酮，苦丁酮 A（1），以及四种新的三萜皂苷，依列苦丁糖苷 A-D（2-5），此外还分离得到了八种已知的三萜类化合物。这些新化合物通过包括 1D 和 2D NMR、HR-TOF-MS 和 CD 光谱在内的光谱方法进行了阐明。化合物 2、3、12 和 13 对金黄色葡萄球菌（SA）和耐甲氧西林金黄色葡萄球菌（MRSA）具有抗菌活性。