免疫与疾病中的 DNA 识别。
DNA recognition in immunity and disease.
机构信息
Department of Biomedicine, Wilhelm Meyers Allé 4, University of Aarhus, 8000 Aarhus, Denmark.
出版信息
Curr Opin Immunol. 2013 Feb;25(1):13-8. doi: 10.1016/j.coi.2012.12.006. Epub 2013 Jan 9.
Abstract
Great progress has been made in understanding how immune cells detect microbial pathogens. An area that has received particular attention is nucleic acid sensing where RNA and DNA sensing machineries have been uncovered. For DNA, TLR9 in endosomes and numerous cytoplasmic DNA binding proteins have been identified. Several of these have been proposed to couple DNA recognition to induction of type I IFNs, pro-inflammatory cytokines and/or caspase-1 activation. Given the ubiquitous expression of many of these DNA binding proteins and the significant potential for endogenous DNA to engage these molecules, it is important that DNA recognition is tightly regulated. A better understanding of DNA recognition pathways can provide new insights into infectious, inflammatory and autoimmune diseases.
摘要
在理解免疫细胞如何检测微生物病原体方面已经取得了很大的进展。一个受到特别关注的领域是核酸感应，其中已经发现了 RNA 和 DNA 感应机制。对于 DNA，内体中的 TLR9 和许多细胞质 DNA 结合蛋白已经被确定。其中一些被提出将 DNA 识别与 I 型 IFNs、促炎细胞因子和/或 caspase-1 激活偶联。鉴于许多这些 DNA 结合蛋白的广泛表达以及内源性 DNA 与这些分子结合的巨大潜力，DNA 识别受到严格调控非常重要。对 DNA 识别途径的更好理解可以为传染病、炎症和自身免疫性疾病提供新的见解。
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