School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Eur J Med Chem. 2013 Feb;60:263-70. doi: 10.1016/j.ejmech.2012.12.022. Epub 2012 Dec 26.
In order to find out new natural barrigenol type triterpenenoids as antitumor agent and reveal the difference on material basis of different parts of Xanthoceras sorbifolia Bunge, the bioassay-directed separation of the saponin fraction from leaves of X. sorbifolia Bunge was carried out to afford 5 new barrigenol type triterpenoids (1-5), together with 2 known ones. The antitumor activities were evaluated and compounds 2 and 7 showed significant cytotoxic activity. Furthermore, the SAR was discussed briefly. On the basis of our research work and related literature, the difference of chemical constituents from different parts of X. sorbifolia was analyzed and concluded. The result can be a useful reference for phytochemistry taxology and safe and rational drug use of X. sorbifolia.
为了寻找新的天然巴尔吉醇型三萜类化合物作为抗肿瘤药物，并揭示不同部位物质基础的差异，对文冠果叶的皂苷部分进行了生物活性导向分离，得到了 5 个新的巴尔吉醇型三萜类化合物（1-5），以及 2 个已知化合物。对其抗肿瘤活性进行了评价，化合物 2 和 7 表现出显著的细胞毒性活性。此外，还简要讨论了构效关系。基于我们的研究工作和相关文献，分析并总结了文冠果不同部位化学成分的差异。研究结果可为文冠果的植物化学分类学和安全合理用药提供有益参考。
