嗅觉缺失和海马体体积减少可用于阿尔茨海默病的早期诊断：一项初步研究。
Olfactory deficit and hippocampal volume loss for early diagnosis of Alzheimer disease: a pilot study.
机构信息
Departments of *Aging Science †Radiology, Umberto I Hospital, Sapienza, University of Rome, Rome Departments of ‡Applied Sciences, ENT §Applied Sciences, Section of Clinical Epidemiology, University of L'Aquila, L'Aquila, Italy.
出版信息
Alzheimer Dis Assoc Disord. 2014 Apr-Jun;28(2):194-7. doi: 10.1097/WAD.0b013e31827bdb9f.
BACKGROUND
The aim of this pilot study was to verify the role of olfactory test and volumetric magnetic resonance imaging measure of hippocampus to predict conversion from mild cognitive impairment to Alzheimer disease (AD).
MATERIALS AND METHODS
Eighteen patients with amnesic mild cognitive impairment, broadly defined, were followed at 12 months. Hypothesized baseline predictors for follow-up conversion to AD were olfactory deficit and hippocampal volumes loss.
RESULTS
In the 1-year follow-up, 5 patients converted to AD. The 2 clinical predictors olfactory test and hippocampal volume loss showed the same sensitivity of 92.3% but the olfactory test showed a higher specificity than the hippocampal volume loss (75% vs. 60%).
CONCLUSIONS
Our findings suggest the potential utility of olfactory test and hippocampal volume loss for early detection of AD.
背景
本初步研究旨在验证嗅觉测试和海马体容积磁共振成像测量在预测轻度认知障碍向阿尔茨海默病（AD）转化中的作用。
材料和方法
18 名记忆障碍轻度认知障碍患者在 12 个月时进行随访。假设嗅觉缺陷和海马体体积丧失是预测随访中向 AD 转化的基线预测因子。
结果
在 1 年的随访中，有 5 名患者转化为 AD。2 个临床预测因子嗅觉测试和海马体体积丧失的敏感性相同，均为 92.3%，但嗅觉测试的特异性高于海马体体积丧失（75%比 60%）。
结论
我们的研究结果表明，嗅觉测试和海马体体积丧失在 AD 的早期检测中具有潜在的应用价值。
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