Department of Biological Sciences, State University of Feira de Santana (UEFS), Av. Transnordestina, S/N, Novo Horizonte, Feira de Santana, Bahia, 44036-900, Brazil,
J Nat Med. 2013 Oct;67(4):743-9. doi: 10.1007/s11418-012-0738-8. Epub 2013 Jan 13.
α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects. The present study investigated the antinociceptive and anti-inflammatory effects of EC. Intraperitoneal administration of EC at doses of 100, 200 or 300 mg/kg promoted a significant antinociceptive effect, as shown in the acetic acid-induced abdominal writhing test. EC also provoked a reduction in formalin-induced nociception in the first (300 mg/kg) and second phases (200 and 300 mg/kg). In the hot-plate test, an increase in response latency was found at 30 min (at 100, 200 and 300 mg/kg), and at 60 and 120 min (at 300 mg/kg) following administration of EC, an effect that was reversed by naloxone. Intraperitoneal administration of EC (300 mg/kg) inhibited the increased vascular permeability provoked by acetic acid. These findings suggest that EC inhibited the acute inflammatory reaction, with a pronounced peripheral and central antinociceptive effect in mice that is probably associated with activation of the opioidergic system, which appears to play a role in the antinociceptive activity induced by EC.
α,β-环氧香芹酮（EC）是一种存在于许多植物精油中的单萜烯。它也可以通过有机合成获得。EC 对中枢神经系统有抑制作用，也具有抗惊厥、抗菌和抗氧化作用。本研究调查了 EC 的镇痛和抗炎作用。腹腔内给予 100、200 或 300 mg/kg 的 EC 剂量可显著促进镇痛作用，如在醋酸诱导的腹部扭曲试验中所示。EC 还可减少福尔马林诱导的第一期（300 mg/kg）和第二期（200 和 300 mg/kg）的疼痛。在热板试验中，在给予 EC 后 30 分钟（在 100、200 和 300 mg/kg 时）和 60 分钟和 120 分钟（在 300 mg/kg 时）观察到反应潜伏期增加，这种作用被纳洛酮逆转。腹腔内给予 EC（300 mg/kg）抑制了醋酸引起的血管通透性增加。这些发现表明，EC 抑制了急性炎症反应，在小鼠中具有明显的外周和中枢镇痛作用，这可能与阿片能系统的激活有关，阿片能系统似乎在 EC 诱导的镇痛活性中发挥作用。
