Department of Physiology, Universidade Federal de Sergipe (DFS/UFS), Aracaju, SE, Brazil.
Z Naturforsch C J Biosci. 2012 Jan-Feb;67(1-2):15-21. doi: 10.1515/znc-2012-1-203.
We attempted to identify the antinociceptive and anti-inflammatory actions of the monoterpene p-cymene. Firstly, behavioural screening was carried out to verify the influence of p-cymene [25, 50, and 100 mg/kg intraperitoneal (i.p.)] on the central nervous system (CNS) activity. The antinociceptive activity of p-cymene was evaluated by the acetic acid-induced writhing response, formalin, and hot-plate test, respectively. The leukocyte migration induced by injection of carrageenan was used to assess the anti-inflammatory activity. p-Cymene showed depressant activity on CNS after 4 h of treatment and also a possible action on the autonomous nervous system (ANS), mainly at the dose of 100 mg/kg (i.p.). It was found that p-cymene (50 and 100 mg/kg, i.p.) significantly (p < 0.05) reduced the writhing responses induced by acetic acid. p-Cymene also decreased the licking time in the first and second phase, respectively, of the formalin test. The results of the hot-plate test showed that all doses of p-cymene increased significantly the latency time of the response to the thermal stimulus in both licking and jumping parameters. In addition, there was a significantly (p < 0.05) decreased leukocyte migration at all doses of p-cymene. The experimental data demonstrate that p-cymene possesses antinociceptive and anti-inflammatory activities.
我们试图确定单萜 p- 桧烯的镇痛和抗炎作用。首先，进行行为筛选以验证 p- 桧烯 [25、50 和 100mg/kg 腹腔内 (i.p.)] 对中枢神经系统 (CNS) 活性的影响。通过醋酸诱导的扭体反应、福氏完全佐剂和热板试验分别评估 p- 桧烯的镇痛活性。通过注射角叉菜胶诱导白细胞迁移来评估抗炎活性。p- 桧烯在治疗 4 小时后对中枢神经系统表现出抑制作用，并且可能对自主神经系统 (ANS) 起作用，主要在 100mg/kg (i.p.) 剂量下。发现 p- 桧烯 (50 和 100mg/kg，i.p.) 显著 (p<0.05) 减少了醋酸诱导的扭体反应。p- 桧烯还分别减少了福尔马林试验中第一和第二阶段的舔舐时间。热板试验的结果表明，p- 桧烯的所有剂量均显著增加了舔舐和跳跃参数对热刺激的反应潜伏期。此外，p- 桧烯的所有剂量均显著 (p<0.05) 减少了白细胞迁移。实验数据表明 p- 桧烯具有镇痛和抗炎作用。
