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衰老的表观遗传和小 RNA 调控。

Epigenetic and small RNA regulation of senescence.

机构信息

Institute of Biology, Martin-Luther-University Halle-Wittenberg, Weinbergweg 10, 06120, Halle, Germany.

出版信息

Plant Mol Biol. 2013 Aug;82(6):529-37. doi: 10.1007/s11103-012-0005-0. Epub 2013 Jan 13.

DOI:10.1007/s11103-012-0005-0
PMID:23315005
Abstract

Leaf senescence is regulated through a complex regulatory network triggered by internal and external signals for the reprogramming of gene expression. In plants, the major developmental phase transitions and stress responses are under epigenetic control. In this review, the underlying molecular mechanisms are briefly discussed and evidence is shown that epigenetic processes are also involved in the regulation of leaf senescence. Changes in the chromatin structure during senescence, differential histone modifications determining active and inactive sites at senescence-associated genes and DNA methylation are addressed. In addition, the role of small RNAs in senescence regulation is discussed.

摘要

叶片衰老受内部和外部信号调控,通过一个复杂的调控网络来重新编程基因表达。在植物中,主要的发育阶段转变和应激反应受表观遗传控制。在这篇综述中,简要讨论了潜在的分子机制,并表明表观遗传过程也参与了叶片衰老的调控。讨论了衰老过程中染色质结构的变化、决定衰老相关基因活性和非活性位点的差异组蛋白修饰以及 DNA 甲基化,此外还讨论了小 RNA 在衰老调控中的作用。

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本文引用的文献

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Variations in the DNA methylation and polypeptide patterns of adult hazel (Corylus avellana L.) associated with sequential in vitro subcultures.与连续体外传代相关的成年榛(Corylus avellana L.)的 DNA 甲基化和多肽模式的变化。
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POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in .POWERDRESS 与 HISTONE DEACETYLASE 9 相互作用,促进. 的衰老。
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