Thorstensen Tage, Grini Paul E, Aalen Reidunn Birgitta
Department of Molecular Biosciences, University of Oslo, Oslo, Norway.
Biochim Biophys Acta. 2011 Aug;1809(8):407-20. doi: 10.1016/j.bbagrm.2011.05.008. Epub 2011 May 23.
Post-translational methylation of lysine residues on histone tails is an epigenetic modification crucial for regulation of chromatin structure and gene expression in eukaryotes. The majority of the histone lysine methyltransferases (HKMTases) conferring such modifications are proteins with a conserved SET domain responsible for the enzymatic activity. The SET domain proteins in the model plant Arabidopsis thaliana can be assigned to evolutionarily conserved classes with different specificities allowing for different outcomes on chromatin structure. Here we review the present knowledge of the biochemical and biological functions of plant SET domain proteins in developmental processes. This article is part of a Special Issue entitled: Epigenetic control of cellular and developmental processes in plants.
组蛋白尾部赖氨酸残基的翻译后甲基化是一种表观遗传修饰，对真核生物中染色质结构的调控和基因表达至关重要。赋予此类修饰的大多数组蛋白赖氨酸甲基转移酶（HKMTases）是具有负责酶活性的保守SET结构域的蛋白质。模式植物拟南芥中的SET结构域蛋白可分为具有不同特异性的进化保守类别，这些特异性会导致染色质结构产生不同结果。在这里，我们综述了植物SET结构域蛋白在发育过程中的生化和生物学功能的现有知识。本文是名为：植物细胞和发育过程的表观遗传控制的特刊的一部分。
