Department of Otolaryngology, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey.
Dysphagia. 2013 Sep;28(3):382-7. doi: 10.1007/s00455-012-9444-7. Epub 2013 Jan 13.
The aim of this study was to investigate the existence of Helicobacter pylori (HP) in patients with benign and malignant vocal fold pathologies. This was a prospective clinical study conducted at a tertiary-care academic medical center. Fifty consecutive patients who had undergone microlaryngoscopy between August 2007 and July 2009 were included in the study. The patients with a reflux symptom index (RSI) above 12 and a reflux finding score (RFS) above 6 were accepted as having laryngopharyngeal reflux. Patients with urea breath test (UBT), HP-IgG, and HP cytotoxin-associated gene A (CagA)-IgG positivity were diagnosed as HP positive. During laryngoscopy, two surgical specimens were obtained, one from the primary vocal fold pathology and one from the interarytenoid region. The interarytenoid biopsy specimen was used for HP culture and PCR. The specimen from the vocal fold pathology was used to investigate the presence of HP. RSI was positive in 23 (46%) patients. The RFS positivity was 56%. The presence of HP was confirmed by UBT in 35 (70%), HP-IgG in 37 (74%), and HP CagA-IgG in 38 (76%) patients. There was no difference between RFS-positive and RFS-negative patients in terms of HP-IgG and UBT. None of the interarytenoid or vocal fold specimens showed the presence of HP. HP was not found in the histological specimens of vocal fold pathologies and the interarytenoid region. The presence of HP in the gastric mucosa does not have an effect on the RFS and RSI.
本研究旨在探讨幽门螺杆菌（HP）在良性和恶性声带病变患者中的存在情况。这是一项在三级学术医疗中心进行的前瞻性临床研究。2007 年 8 月至 2009 年 7 月期间，共有 50 例接受喉显微手术的连续患者纳入本研究。RSI 超过 12，RFS 超过 6 的患者被认为存在喉咽反流。尿素呼气试验（UBT）、HP-IgG 和 HP 细胞毒素相关基因 A（CagA）-IgG 阳性的患者被诊断为 HP 阳性。在喉镜检查期间，从原发性声带病变和杓状软骨间区域获得两个手术标本。杓状软骨活检标本用于 HP 培养和 PCR。声带病变标本用于研究 HP 的存在情况。23 例（46%）患者 RSI 阳性，RFS 阳性率为 56%。35 例（70%）患者通过 UBT 证实存在 HP，37 例（74%）患者 HP-IgG 阳性，38 例（76%）患者 HP CagA-IgG 阳性。在 RFS 阳性和 RFS 阴性患者中，HP-IgG 和 UBT 无差异。在杓状软骨和声带病变标本中均未发现 HP。HP 未在声带病变和杓状软骨组织学标本中检出。胃黏膜中 HP 的存在对 RFS 和 RSI 没有影响。
