Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences Hospital, Kaunas Clinic, Eiveniu 2, Kaunas, 50009, Lithuania.
Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2283-8. doi: 10.1007/s00405-013-2475-3. Epub 2013 Apr 10.
Clinical studies have shown that Helicobacter pylori can be found not only in the mucosa of the stomach, but in the pharyngeal and laryngeal regions as well. The aim of this prospective case-control study was to identify H. pylori infection in the biopsy material from the larynx of the patients suffering from benign laryngeal diseases (vocal fold polyps, laryngitis) and laryngeal cancer and to investigate the possible relationships between the laryngeal H. pylori and patients' socio-demographic data and laryngopharyngeal reflux. The results of the biopsy material from 67 adult patients treated for benign laryngeal diseases and laryngeal cancer and 11 individuals of the control group revealed that H. pylori infection could be identified in more than one-third of the patients. In the majority of cases H. pylori was found in the patients with chronic laryngitis (45.5%) and laryngeal cancer (46.2%). The findings of these sub-groups significantly differed from those of the control group (9.1%) (p < 0.05). No significant relationships between H. pylori infection found in the laryngeal region and patients' demographic data, their unhealthy habits and reflux-related symptoms or signs were obtained. It could be concluded that H. pylori can colonize in the larynx of patients with benign laryngeal diseases and laryngeal cancer. To clarify the role of H. pylori as a risk factor for laryngeal diseases further research is needed.
临床研究表明，幽门螺杆菌不仅存在于胃黏膜中，也存在于咽和喉部。本前瞻性病例对照研究旨在确定患有良性喉部疾病（声带息肉、喉炎）和喉癌的患者的喉部活检组织中是否存在 H. pylori 感染，并研究喉 H. pylori 与患者社会人口统计学数据和喉咽反流之间的可能关系。对 67 名成年患者（良性喉部疾病和喉癌）和 11 名对照组患者的活检组织进行了检测，结果显示，超过三分之一的患者存在 H. pylori 感染。在大多数情况下，慢性喉炎（45.5%）和喉癌（46.2%）患者中发现了 H. pylori。这些亚组的结果与对照组（9.1%）有显著差异（p < 0.05）。在喉部发现的 H. pylori 感染与患者的人口统计学数据、不良习惯和反流相关症状或体征之间未发现显著关系。研究结果表明，H. pylori 可定植于良性喉部疾病和喉癌患者的喉部。为了进一步阐明 H. pylori 作为喉部疾病危险因素的作用，需要进一步研究。
