在感染 HIV-1 早期，C 亚型和非 C 亚型感染的非洲血清转换者的血浆病毒载量相似。
Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.
机构信息
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
出版信息
J Infect Dis. 2013 Apr;207(7):1166-70. doi: 10.1093/infdis/jit015. Epub 2013 Jan 11.
Abstract
Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.
摘要
最近的数据表明，感染人类免疫缺陷病毒 1 型（HIV-1）亚型 C 会导致早期感染期间高水平的持续性病毒血症（>5 log10 拷贝/mL）。我们在 153 名非洲血清转化者中研究了 HIV-1 亚型与血浆病毒血症之间的关系。C 型和非 C 型的平均设定点病毒载量相似：4.36 对 4.42 log10 拷贝/mL（P =.61）。病毒载量>5 log10 拷贝/mL 的 C 型感染参与者的比例并不高于非 C 感染的参与者。我们的数据不支持这样的假设，即较高的早期病毒载量是 HIV-1 亚型 C 在南非迅速传播的原因。
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本文引用的文献
1
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AIDS Res Hum Retroviruses. 2013 Jan;29(1):164-71. doi: 10.1089/AID.2012.0206.
2
Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples.非洲 HIV-1 血清不一致的夫妇中单次性行为 HIV-1 感染性的决定因素。
J Infect Dis. 2012 Feb 1;205(3):358-65. doi: 10.1093/infdis/jir747. Epub 2012 Jan 11.
3
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.全基因组关联研究确定 HIV-1 血清学不一致夫妇中 HIV-1 获得和病毒设定点的决定因素，这些夫妇存在量化的病毒暴露。
PLoS One. 2011;6(12):e28632. doi: 10.1371/journal.pone.0028632. Epub 2011 Dec 12.
4
High clade C HIV-1 viremia: how did we get here and where are we going?高C亚型HIV-1病毒血症：我们如何走到这一步，又将何去何从？
AIDS. 2011 Jul 31;25(12):1543-5. doi: 10.1097/QAD.0b013e328348a4d2.
5
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AIDS. 2011 Jul 31;25(12):1515-22. doi: 10.1097/QAD.0b013e3283471eb2.
6
Global trends in molecular epidemiology of HIV-1 during 2000-2007.2000-2007 年期间 HIV-1 分子流行病学的全球趋势。
AIDS. 2011 Mar 13;25(5):679-89. doi: 10.1097/QAD.0b013e328342ff93.
7
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8
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9
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10
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