鼠伤寒沙门氏菌中一种酸诱导性硫酸酯酶的特性研究。
Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium.
机构信息
Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
出版信息
Appl Environ Microbiol. 2013 Mar;79(6):2092-5. doi: 10.1128/AEM.03707-12. Epub 2013 Jan 11.
Abstract
Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.
摘要
肠细菌的硫酸酯酶可以提供大量硫酸化黏膜聚糖的途径。在这项研究中，我们表明，鼠伤寒沙门氏菌血清型 LT2 的 aslA（STM0084）编码一种硫酸酯酶，其表达和活性需要微酸性 pH 值。AslA 不受硫化合物或酪胺调节，但需要 EnvZ-OmpR 和 PhoPQ 调节系统，该系统在发病机制中起重要作用。
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