• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Acetylcholinesterase: old questions and new developments.

作者信息

Tsim Karl, Soreq Hermona

机构信息

Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology Hong Kong, China.

出版信息

Front Mol Neurosci. 2013 Jan 9;5:101. doi: 10.3389/fnmol.2012.00101. eCollection 2012.

DOI:10.3389/fnmol.2012.00101
PMID:23316131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3540815/
Abstract
摘要

相似文献

1
Acetylcholinesterase: old questions and new developments.乙酰胆碱酯酶：旧问题与新进展
Front Mol Neurosci. 2013 Jan 9;5:101. doi: 10.3389/fnmol.2012.00101. eCollection 2012.
2
Recent developments in structural studies on acetylcholinesterase.乙酰胆碱酯酶结构研究的最新进展。
J Neurochem. 2017 Aug;142 Suppl 2:19-25. doi: 10.1111/jnc.13992. Epub 2017 May 15.
3
Rational design of reversible acetylcholinesterase inhibitors.
Mini Rev Med Chem. 2002 Feb;2(1):27-36. doi: 10.2174/1389557023406494.
4
Acetylcholinesterase--new roles for an old actor.乙酰胆碱酯酶——老角色的新作用。
Nat Rev Neurosci. 2001 Apr;2(4):294-302. doi: 10.1038/35067589.
5
Glutamate-elicited stimulation of acetylcholinesterase activity in cerebellar slices from newborn rats.
Neurosci Res. 1986 Jul;3(5):395-402. doi: 10.1016/0168-0102(86)90031-3.
6
Acetylcholinesterase and apoptosis. A novel perspective for an old enzyme.
FEBS J. 2008 Feb;275(4):612-7. doi: 10.1111/j.1742-4658.2007.06236.x. Epub 2008 Jan 17.
7
A noncholinergic action of acetylcholinesterase (AChE) in the brain: from neuronal secretion to the generation of movement.乙酰胆碱酯酶（AChE）在大脑中的非胆碱能作用：从神经元分泌到运动的产生。
Cell Mol Neurobiol. 1991 Feb;11(1):55-77. doi: 10.1007/BF00712800.
8
Continuum diffusion reaction rate calculations of wild-type and mutant mouse acetylcholinesterase: adaptive finite element analysis.野生型和突变型小鼠乙酰胆碱酯酶的连续介质扩散反应速率计算：自适应有限元分析
Biophys J. 2004 Sep;87(3):1558-66. doi: 10.1529/biophysj.104.041517.
9
Recent developments in the synthesis of acetylcholinesterase inhibitors.乙酰胆碱酯酶抑制剂合成的最新进展。
Mini Rev Med Chem. 2003 Sep;3(6):518-24. doi: 10.2174/1389557033487908.
10
Muscarinic cholinergic receptor regulation and acetylcholinesterase inhibition in response to insecticide exposure during development.
Int J Dev Neurosci. 1994 Feb;12(1):63-75. doi: 10.1016/0736-5748(94)90097-3.

引用本文的文献

1
Synthesis, Biological Evaluation, and In Silico Characterization of Novel Imidazothiadiazole-Chalcone Hybrids as Multi-Target Enzyme Inhibitors.新型咪唑并噻二唑-查尔酮杂化物作为多靶点酶抑制剂的合成、生物学评价及计算机模拟表征
Pharmaceuticals (Basel). 2025 Jun 26;18(7):962. doi: 10.3390/ph18070962.
2
Butylated Hydroxyanisole (BHA) Disrupts Brain Signalling in Embryo-Larval Stage of Zebrafish Leading to Attention Deficit Hyperactivity Disorder (ADHD).丁基羟基茴香醚（BHA）扰乱斑马鱼胚胎-幼虫阶段的脑信号传导，导致注意力缺陷多动障碍（ADHD）。
J Xenobiot. 2025 Jul 9;15(4):116. doi: 10.3390/jox15040116.
3
Advances in Cholinesterase Inhibitor Research-An Overview of Preclinical Studies of Selected Organoruthenium(II) Complexes.胆碱酯酶抑制剂研究进展——部分有机钌（II）配合物的临床前研究概述。
Int J Mol Sci. 2024 Aug 21;25(16):9049. doi: 10.3390/ijms25169049.
4
Comparative transcriptome and methylome of polar bears, giant and red pandas reveal diet-driven adaptive evolution.北极熊、大熊猫和小熊猫的比较转录组和甲基化组揭示了饮食驱动的适应性进化。
Evol Appl. 2024 Jun 17;17(6):e13731. doi: 10.1111/eva.13731. eCollection 2024 Jun.
5
Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of () on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study.（）叶和种子提取物对四氧嘧啶诱导糖尿病小鼠的降血糖作用评价：生化和组织学研究。
Oxid Med Cell Longev. 2023 May 12;2023:9136217. doi: 10.1155/2023/9136217. eCollection 2023.
6
Novel Organoruthenium(II) Complex C1 Selectively Inhibits Butyrylcholinesterase without Side Effects on Neuromuscular Transmission.新型有机钌（II）配合物 C1 选择性抑制丁酰胆碱酯酶而不影响神经肌肉传递。
Int J Mol Sci. 2023 Jan 31;24(3):2681. doi: 10.3390/ijms24032681.
7
Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex.黄连、黄柏和防己中生物碱对乙酰胆碱酯酶的协同抑制作用。
Molecules. 2019 Dec 13;24(24):4567. doi: 10.3390/molecules24244567.
8
Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro.岩藻黄质，一种海洋类胡萝卜素，可逆转东莨菪碱诱导的小鼠认知障碍并在体外抑制乙酰胆碱酯酶。
Mar Drugs. 2016 Mar 25;14(4):67. doi: 10.3390/md14040067.
9
Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia.海洋胶原蛋白肽对围产期窒息雄性大鼠生理和神经行为发育的影响
Mar Drugs. 2015 Jun 5;13(6):3653-71. doi: 10.3390/md13063653.
10
Non-synaptic roles of acetylcholinesterase and agrin.乙酰胆碱酯酶和集聚蛋白的非突触作用。
J Mol Neurosci. 2014 Jul;53(3):454-60. doi: 10.1007/s12031-013-0188-0. Epub 2013 Dec 11.

本文引用的文献

1
Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice.血清胆碱酯酶在正常和肌营养不良蛋白缺陷突变小鼠中受到差异调节。
Front Mol Neurosci. 2012 Jun 19;5:73. doi: 10.3389/fnmol.2012.00073. eCollection 2012.
2
Acetylcholinesterase (AChE) is an important link in the apoptotic pathway induced by hyperglycemia in Y79 retinoblastoma cell line.乙酰胆碱酯酶 (AChE) 在高糖诱导的 Y79 视网膜母细胞瘤细胞系凋亡途径中是一个重要的环节。
Front Mol Neurosci. 2012 Jun 6;5:69. doi: 10.3389/fnmol.2012.00069. eCollection 2012.
3
Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis.乙酰胆碱酯酶削弱了大脑的胆碱能抗炎反应，促进了癫痫发生。
Front Mol Neurosci. 2012 May 18;5:66. doi: 10.3389/fnmol.2012.00066. eCollection 2012.
4
Early appearance and possible functions of non-neuromuscular cholinesterase activities.非神经肌肉乙酰胆碱酯酶活性的早期表现和可能的功能。
Front Mol Neurosci. 2012 Apr 20;5:54. doi: 10.3389/fnmol.2012.00054. eCollection 2012.
5
Acetylcholinesterase involvement in apoptosis.乙酰胆碱酯酶与细胞凋亡的关系。
Front Mol Neurosci. 2012 Apr 10;5:40. doi: 10.3389/fnmol.2012.00040. eCollection 2012.
6
Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons.调控神经元乙酰胆碱酯酶 mRNA 代谢的反式作用因子。
Front Mol Neurosci. 2012 Mar 22;5:36. doi: 10.3389/fnmol.2012.00036. eCollection 2012.
7
Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions.强调造血和免疫：乙酰胆碱酯酶揭示神经系统与免疫系统的相互作用。
Front Mol Neurosci. 2012 Mar 16;5:30. doi: 10.3389/fnmol.2012.00030. eCollection 2012.
8
Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation.脑和肌肉中乙酰胆碱酯酶的分子组装和生物合成：t 肽、FHB 结构域和 N-糖基化的作用。
Front Mol Neurosci. 2011 Oct 25;4:36. doi: 10.3389/fnmol.2011.00036. eCollection 2011.
9
Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes.计算机筛选的靶向胆碱酯酶的 microRNAs 影响特定的生物学过程。
Front Mol Neurosci. 2011 Oct 5;4:28. doi: 10.3389/fnmol.2011.00028. eCollection 2011.
10
Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid.重新审视乙酰胆碱酯酶在阿尔茨海默病中的作用：与 p- tau 和 β- 淀粉样蛋白的相互作用。
Front Mol Neurosci. 2011 Sep 13;4:22. doi: 10.3389/fnmol.2011.00022. eCollection 2011.