Nyborn Justin A, Himali Jayandra J, Beiser Alexa S, Devine Sherral A, Du Yangchun, Kaplan Edith, O'Connor Maureen K, Rinn William E, Denison Helen S, Seshadri Sudha, Wolf Philip A, Au Rhoda
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Exp Aging Res. 2013;39(1):80-108. doi: 10.1080/0361073X.2013.741996.
BACKGROUND/STUDY CONTEXT: Although the Clock Drawing Test (CDT) is a popular tool used to assess cognitive function, limited normative data on CDT performance exist. The objective of the current study was to provide normative data on an expanded version of previous CDT scoring protocols from a large community-based sample of middle to older adults (aged 43 to 91) from the Framingham Heart Study.
The CDT was administered to 1476 Framingham Heart Study Offspring Cohort participants using a scoring protocol that assigned error scores to drawn features. Total error scores were computed, as well as for subscales pertaining to outline, numeral placement, time-setting, center, and "other."
Higher levels of education were significantly associated with fewer errors for time-setting (Command: p < .001; Copy: p = .003), numerals (Command: p < .001), and "other" (Command: p < .001) subscales. Older age was significantly associated with more errors for time-setting (Command: p < .001; Copy: p = .003), numerals (Command: p < .001), and "other" (Command: p < .001) subscales. Significant differences were also found between education groups on the Command condition for all but the oldest age group (75+).
Results provide normative data on CDT performance within a community-based cohort. Errors appear to be more prevalent in older compared with younger individuals, and may be less prevalent in individuals who completed at least some college compared with those who did not. Future studies are needed to determine whether this expanded scoring system allows detection of preclinical symptoms of future risk for dementia.
背景/研究背景:尽管画钟试验(CDT)是一种用于评估认知功能的常用工具,但关于CDT表现的规范数据有限。本研究的目的是从弗雷明汉心脏研究中一个以社区为基础的中老年人群(43至91岁)大样本中,提供关于先前CDT评分协议扩展版本的规范数据。
使用一种为所画特征分配错误分数的评分协议,对1476名弗雷明汉心脏研究后代队列参与者进行画钟试验。计算总错误分数以及与轮廓、数字位置、时间设定、中心和“其他”相关的子量表的错误分数。
较高的教育水平与时间设定(指令:p <.001;临摹:p =.003)、数字(指令:p <.001)和“其他”(指令:p <.001)子量表的错误较少显著相关。年龄较大与时间设定(指令:p <.001;临摹:p =.003)、数字(指令:p <.001)和“其他”(指令:p <.001)子量表的错误较多显著相关。除最年长年龄组(75岁以上)外,在指令条件下,各教育组之间也发现了显著差异。
研究结果提供了基于社区队列中CDT表现的规范数据。与年轻人相比,错误在老年人中似乎更普遍,与未完成至少一些大学学业的人相比,在至少完成了一些大学学业的个体中可能不太普遍。未来需要进行研究,以确定这种扩展的评分系统是否能够检测出未来患痴呆症风险的临床前症状。