Department of Physical Education and Sport, School of Sport Sciences, University of Granada, Granada, Spain.
Scand J Med Sci Sports. 2013 Jun;23(3):e162-7. doi: 10.1111/sms.12045. Epub 2013 Jan 14.
The aim of the present case-control study was to examine the association of the ACTN3 R577X genotype with elite swimming status. We compared a group of Spanish (Caucasian) elite swimmers (n = 88) with other cohorts of the same ethnic origin, i.e., nonathletic controls (n = 343) and other types of athletes who are in both end-points of the sports performance continuum, i.e., world-class power (n = 119) and endurance male athletes (n = 154). Swimmers had a lower odds ratio (OR) of having the RX genotype [1.815, 95% confidence intervals (CI): 0.899-3.664] compared with nonathletic controls, yet the association did not reach statistical significance (P = 0.096). Endurance athletes had greater OR of having the XX genotype (OR: 2.88, 95% CI: 1.162-7.135, P = 0.022), or the RX+XX genotype (OR: 1.903, 95% CI: 1.015-3.567, P = 0.045) compared with swimmers. No other association was found. In summary, we did not observe an association between the ACTN3 R577X polymorphism and elite swimmer's status, suggesting that any influence of this polymorphism is not of sufficient magnitude as to significantly influence elite swimming performance, at least in Spanish athletes.
本病例对照研究旨在探讨 ACTN3 R577X 基因型与精英游泳运动员身份的关联。我们比较了一组西班牙（白种人）精英游泳运动员（n=88）与具有相同种族来源的其他队列，即非运动员对照组（n=343）和其他类型的运动员，他们处于运动表现连续体的两个端点，即世界级力量（n=119）和耐力男性运动员（n=154）。与非运动员对照组相比，游泳运动员具有较低的 RX 基因型的优势比（OR）[1.815，95%置信区间（CI）：0.899-3.664]，但关联没有达到统计学意义（P=0.096）。耐力运动员具有更高的 XX 基因型的优势比（OR：2.88，95% CI：1.162-7.135，P=0.022），或 RX+XX 基因型的优势比（OR：1.903，95% CI：1.015-3.567，P=0.045），与游泳运动员相比。没有发现其他关联。总之，我们没有观察到 ACTN3 R577X 多态性与精英游泳运动员身份之间存在关联，这表明该多态性的任何影响都不足以显著影响精英游泳表现，至少在西班牙运动员中是如此。
