口腔和口咽癌患者的脂质过氧化与抗氧化维生素状态
Lipid peroxidation and antioxidant vitamin status in oral cavity and oropharyngeal cancer patients.
作者信息
Marakala Vijaya, Malathi M, Shivashankara A R
机构信息
Department of Biochemistry, Srinivas Institute of Medical Science and Research Centre, Mukka, Surathkal, India.
出版信息
Asian Pac J Cancer Prev. 2012;13(11):5763-5. doi: 10.7314/apjcp.2012.13.11.5763.
BACKGROUND
This study was conducted to determine levels of lipid peroxidation and antioxidant vitamin status in patients with oral cavity and oropharyngeal cancer.
METHODS
The study group consisted of a total number of 80 subjects between the age 40-68 years, 40 with clinically and histopathologically proved cases of oral cavity and oropharyngeal cancer and 40 normal healthy, age and sex matched volunteers as controls. Levels of lipid peroxidation products as malondialdehyde (MDA) and antioxidant vitamins as vitamin A and vitamin C were estimated and compared between the two groups.
RESULTS
There was a statistical significant difference in the mean MDA, plasma vitamin A and vitamin C in the oral and oropharyngeal cancer patients compared with the healthy controls (p<0.0001).
CONCLUSIONS
Lipid peroxidation (MDA) is higher and plasma antioxidant vitamins like vitamin A and vitamin C were lower in oral cavity and oropharyngeal cancer patients than healthy controls.
背景
本研究旨在确定口腔和口咽癌患者的脂质过氧化水平及抗氧化维生素状态。
方法
研究组共有80名年龄在40 - 68岁之间的受试者，其中40例经临床和组织病理学证实为口腔和口咽癌患者，40名年龄、性别匹配的正常健康志愿者作为对照组。对两组受试者的脂质过氧化产物丙二醛（MDA）水平以及抗氧化维生素维生素A和维生素C水平进行了评估和比较。
结果
与健康对照组相比，口腔和口咽癌患者的平均MDA、血浆维生素A和维生素C水平存在统计学显著差异（p<0.0001）。
结论
与健康对照组相比，口腔和口咽癌患者的脂质过氧化（MDA）水平较高，而血浆抗氧化维生素如维生素A和维生素C水平较低。
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