口腔潜在恶性疾病和口腔癌患者血清及唾液中抗坏血酸的状况
Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer.
作者信息
Bhat Supriya, Babu Subhas Gogineni, Bhat Saidath K, Castelino Renita Lorina, Rao Kumuda, Madi Medhini
机构信息
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India.
Department of Orthodontics, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India.
出版信息
Indian J Med Paediatr Oncol. 2017 Jul-Sep;38(3):306-310. doi: 10.4103/ijmpo.ijmpo_67_16.
BACKGROUND AND AIMS
The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer.
SUBJECTS AND METHODS
A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Data obtained was analyzed using ANOVA test for the comparison between the groups. Tukey's analysis was used for the comparison of the two study groups to the control group. Correlation between the groups was done using Pearson's correlation coefficient test.
RESULTS
The mean serum and salivary Vitamin C levels were decreased significantly in potentially malignant disorders and oral cancer when compared to healthy subjects.
CONCLUSIONS
As significant reduction of Vitamin C is seen in saliva, it can be stated that saliva can be used as a reliable, noninvasive biomarker in diagnosis and management of potentially malignant disorders and oral cancer.
背景与目的
本研究旨在通过评估口腔潜在恶性疾病和口腔癌患者血清及唾液中的维生素C，来估计血清和唾液的解毒状态。
对象与方法
本研究共纳入90名受试者，其中30名口腔潜在恶性疾病患者、30名口腔癌患者以及30名健康受试者（对照组）。收集血清和唾液并评估维生素C水平。对所获数据进行方差分析以比较组间差异。采用Tukey分析比较两个研究组与对照组。使用Pearson相关系数检验进行组间相关性分析。
结果
与健康受试者相比，潜在恶性疾病和口腔癌患者的血清及唾液维生素C平均水平显著降低。
结论
由于唾液中维生素C显著减少，可以认为唾液可作为诊断和管理口腔潜在恶性疾病及口腔癌的可靠、无创生物标志物。
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