Pankratz M J, Seifert E, Gerwin N, Billi B, Nauber U, Jäckle H
Institut für Genetik und Mikrobiologie, München, Federal Republic of Germany.
Cell. 1990 Apr 20;61(2):309-17. doi: 10.1016/0092-8674(90)90811-r.
Abdominal segmentation of the Drosophila embryo requires the activities of the gap genes Krüppel (Kr), knirps (kni), and tailless (tll). They control the expression of the pair-rule gene hairy (h) by activating or repressing independent cis-acting units that generate individual stripes. Kr activates stripe 5 and represses stripe 6, kni activates stripe 6 and represses stripe 7, and tll activates stripe 7. Kr and kni proteins bind strongly to h control units that generate stripes in areas of low concentration of the respective gap gene products and weakly to those that generate stripes in areas of high gap gene expression. These results indicate that Kr and kni proteins form overlapping concentration gradients that generate the periodic pair-rule expression pattern.
果蝇胚胎的腹部体节形成需要裂隙基因Krüppel（Kr）、无尾基因（kni）和无尾（tll）的活性。它们通过激活或抑制独立的顺式作用元件来控制成对规则基因毛状基因（h）的表达，这些元件会产生单独的条纹。Kr激活条纹5并抑制条纹6，kni激活条纹6并抑制条纹7，而tll激活条纹7。Kr和kni蛋白与h控制元件强烈结合，这些元件在各自裂隙基因产物低浓度区域产生条纹，而与在裂隙基因高表达区域产生条纹的元件弱结合。这些结果表明，Kr和kni蛋白形成重叠的浓度梯度，从而产生周期性的成对规则表达模式。
