抗阻训练增加超重/肥胖年轻男性的性激素结合球蛋白。
Resistance training increases SHBG in overweight/obese, young men.
机构信息
Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, UCLA School of Nursing, University of California, Los Angeles, CA, USA.
出版信息
Metabolism. 2013 May;62(5):725-33. doi: 10.1016/j.metabol.2012.12.004. Epub 2013 Jan 12.
OBJECTIVE
Evidence suggests that SHBG affects glycemic control, predicts both T2D and metabolic syndrome, and is low in obese subjects. We sought to determine if resistance exercise training (RT) can increase sex hormone-binding globulin (SHBG) and ameliorate levels of related steroid hormones in overweight/obese, sedentary young men.
MATERIALS/METHODS: 36 participants (BMI 31.4 kg/m(2), age 22 years) were randomized into an RT (12 weeks of training, 3/week) or control group (C, 12 weeks no training), and assessed for changes in SHBG, cortisol, testosterone, free testosterone (FT) and free androgen index (FAI). In addition, body composition and oral glucose tolerance testing was performed.
RESULTS
12 weeks of RT increased SHBG (P=0.01) and decreased FAI (P<0.05) and cortisol (P<0.05) compared to C. FT decreased in RT (P=0.01). Total testosterone did not change in either group. These changes were noted without weight loss, and in concert with increases in lean body mass (P=0.0002 vs C) and decreases in glucose area under the curve (AUC) (P=0.004), insulin AUC (P=0.03), and total (P=0.002) and trunk (P=0.003) fat mass in RT.
CONCLUSION
In overweight/obese young men, RT increases SHBG and lowers FAI in obese young adult men.
目的
有证据表明，性激素结合球蛋白（SHBG）会影响血糖控制，可预测 2 型糖尿病和代谢综合征，且在肥胖人群中水平较低。我们试图确定阻力运动训练（RT）是否可以增加性激素结合球蛋白（SHBG）并改善超重/肥胖、久坐的年轻男性相关类固醇激素的水平。
材料/方法：36 名参与者（BMI 为 31.4kg/m²，年龄 22 岁）被随机分为 RT（12 周的训练，每周 3 次）或对照组（C，12 周不训练），并评估 SHBG、皮质醇、睾酮、游离睾酮（FT）和游离雄激素指数（FAI）的变化。此外，还进行了身体成分和口服葡萄糖耐量测试。
结果
与 C 相比，12 周的 RT 增加了 SHBG（P=0.01），降低了 FAI（P<0.05）和皮质醇（P<0.05）。FT 在 RT 中降低（P=0.01）。两组的总睾酮均未发生变化。这些变化是在没有体重减轻的情况下发生的，并且与瘦体重增加（P=0.0002 比 C）和葡萄糖曲线下面积（AUC）减少（P=0.004）、胰岛素 AUC（P=0.03）以及总脂肪量减少（P=0.002）和躯干脂肪量减少（P=0.003）有关。
结论
在超重/肥胖的年轻男性中，RT 可增加 SHBG 并降低肥胖年轻男性的 FAI。
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