Edith Cowan University Health and Wellness Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Prostate Cancer Prostatic Dis. 2013 Jun;16(2):170-5. doi: 10.1038/pcan.2012.52. Epub 2013 Jan 15.
Previous research has shown exercise to be an effective method to mitigate many adverse treatment-related effects of androgen suppression therapy (AST) but the potential impact of exercise on sexual activity remains unknown. The purpose of this investigation was to report the effect of a 12-week exercise program on sexual activity in prostate cancer patients undergoing AST.
Fifty-seven prostate cancer patients undergoing AST were randomly assigned to an exercise program (resistance and aerobic modes; n=29) or usual care control (n=28). Sexual activity was assessed by the European Organization for Research and Treatment of Cancer prostate cancer-specific quality of life questionnaire (QLQ-PR25).
QLQ-PR25 data were log transformed and analysis of covariance was used to compare sexual activity between groups following the intervention adjusted for baseline activity. No differences in sexual activity were observed between the exercise and control groups before the intervention. There was a significant (P=0.045) adjusted group difference in sexual activity following the 12-week intervention. Patients undergoing usual care decreased sexual activity while patients in the exercise program maintained their level of sexual activity. At baseline, 20.6 and 22.2% of participants in the exercise and control groups reported a major interest in sex (that is, high libido). Following the intervention, the exercise group had a significantly higher percentage of participants reporting a major interest in sex (exercise=17.2% vs control=0%; P=0.024).
Participation in a short-term exercise program resulted in the maintenance of sexual activity in prostate cancer patients undergoing AST.
既往研究表明，运动是减轻雄激素抑制治疗（AST）相关不良反应的有效方法，但运动对性功能的潜在影响尚不清楚。本研究旨在报告为期 12 周的运动方案对接受 AST 的前列腺癌患者性功能的影响。
57 例接受 AST 的前列腺癌患者被随机分配至运动方案（抗阻和有氧运动模式；n=29）或常规护理对照组（n=28）。采用欧洲癌症研究与治疗组织前列腺癌特异性生活质量问卷（QLQ-PR25）评估性功能。
QLQ-PR25 数据经对数转换，采用协方差分析比较干预后调整基线活动的两组间性功能。干预前，运动组与对照组的性功能无差异。12 周干预后，运动组的性功能存在显著调整组间差异（P=0.045）。接受常规护理的患者性功能下降，而运动方案组患者维持其性功能水平。基线时，运动组和对照组分别有 20.6%和 22.2%的参与者表示对性有强烈兴趣（即高性欲）。干预后，运动组报告有强烈性兴趣的参与者比例明显更高（运动组=17.2% vs 对照组=0%；P=0.024）。
参加短期运动方案可维持接受 AST 的前列腺癌患者的性功能。
