Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México, D.F., México.
J Steroid Biochem Mol Biol. 2014 Jan;139:154-8. doi: 10.1016/j.jsbmb.2013.01.005. Epub 2013 Jan 11.
Pregnancy involves diverse changes in brain function that implicate a re-organization in neuronal cytoskeleton. In this physiological state, the brain is in contact with several hormones that it has never been exposed, as well as with very high levels of hormones that the brain has been in touch throughout life. Among the latter hormones are progesterone and estradiol which regulate several brain functions, including learning, memory, neuroprotection, and the display of sexual and maternal behavior. These functions involve changes in the structure and organization of neurons and glial cells that require the participation of cytoskeletal proteins whose expression and activity is regulated by estradiol and progesterone. We have found that the expression pattern of Microtubule Associated Protein 2, Tau, and Glial Fibrillary Acidic Protein changes in a tissue-specific manner in the brain of the rat throughout gestation and the start of lactation, suggesting that these proteins participate in the plastic changes observed in the brain during pregnancy. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.
妊娠涉及大脑功能的多种变化，这暗示了神经元细胞骨架的重新组织。在这种生理状态下，大脑接触到了它从未接触过的几种激素，以及它一生中一直在接触的非常高水平的激素。后者包括孕激素和雌二醇，它们调节包括学习、记忆、神经保护和性及母性行为在内的多种大脑功能。这些功能涉及神经元和神经胶质细胞的结构和组织的变化，这需要细胞骨架蛋白的参与，其表达和活性受雌二醇和孕酮调节。我们发现，微管相关蛋白 2、Tau 和神经胶质纤维酸性蛋白在妊娠和哺乳期大鼠大脑中的表达模式具有组织特异性，这表明这些蛋白参与了妊娠期间大脑中观察到的可塑性变化。本文是专题“妊娠与甾体激素”的一部分。
