CORIA-Université de Rouen, Av. de l'Université, BP 12, F-76801 Saint-Etienne du Rouvray cedex, France.
J Theor Biol. 2013 Apr 7;322:7-16. doi: 10.1016/j.jtbi.2013.01.003. Epub 2013 Jan 11.
A simple model of three competing cell populations (host, immune and tumor cells) is revisited by using a topological analysis and computing observability coefficients. Our aim is to show that a non-conventional analysis might suggest new trends in understanding the interactions of some tumor cells and their environment. The action of some parameter values on the resulting dynamics is investigated. Our results are related to some clinical features, suggesting that this model thus captures relevant phenomena to cell interactions.
本文通过拓扑分析和计算可观系数，重新研究了三种竞争细胞群体（宿主、免疫和肿瘤细胞）的简单模型。我们的目的是表明，一种非传统的分析方法可能会为理解某些肿瘤细胞及其环境的相互作用提供新的趋势。研究了一些参数值对所得动力学的作用。我们的结果与一些临床特征有关，表明该模型因此捕获了与细胞相互作用相关的现象。
