Nrf2 在脂肪细胞和脂肪生物学中的新兴作用。
Emerging role of Nrf2 in adipocytes and adipose biology.
机构信息
Department of Laboratory Medicine and Pathology, University of California, Irvine, USA.
出版信息
Adv Nutr. 2013 Jan 1;4(1):62-6. doi: 10.3945/an.112.003103.
Abstract
Maintenance of a balanced redox state within the cell is of critical importance to a wide variety of biological systems. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a critical regulator of key aspects of the antioxidant defense pathway and has long been a subject of interest regarding conditions of chronic stress such as inflammation and cancer. Recent data have emerged demonstrating that oxidative stress and Nrf2 also play critical roles in the biology of adipose tissue. This review examines data identifying the roles of Nrf2 and oxidative stress in the biological process of adipose cell differentiation as well as the implications of Nrf2 modulation on obesity. Working to understand the complex interplay among Nrf2, oxidative stress, and adipose biology could lead to a variety of possible treatments for obesity and other related disorders.
摘要
细胞内维持氧化还原状态的平衡对各种生物系统至关重要。核因子红细胞衍生 2 样 2（Nrf2）是抗氧化防御途径关键方面的关键调节剂，长期以来一直是炎症和癌症等慢性应激条件的研究对象。最近出现的一些数据表明，氧化应激和 Nrf2 也在脂肪组织的生物学中发挥关键作用。这篇综述检查了确定 Nrf2 和氧化应激在脂肪细胞分化的生物学过程中的作用的数据，以及 Nrf2 调节对肥胖的影响。努力了解 Nrf2、氧化应激和脂肪生物学之间的复杂相互作用，可能会为肥胖症和其他相关疾病的各种可能治疗方法提供思路。
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