Immunology Research Institute in Gifu; EW Nutrition Japan; Sano, Gifu Japan.
Hum Vaccin Immunother. 2013 May;9(5):1039-48. doi: 10.4161/hv.23383. Epub 2013 Jan 14.
This commentary summarizes the laboratory investigations and clinical trials published recently involving per-oral application of IgY supplemented food for specific orogastrointestinal disease prevention and control purposes. The prolonged use and misuse of conventional antibacterial drugs has spawned antibiotic resistant microbes prompting scientists to search for other germ-killing options. In particular, the use of IgY as a novel mode of immunotherapy using oral chicken immunoglobulin (IgY) to confer passive immunity has gained much interest as an inexpensive non-antibiotic alternative for the prophylaxis and treatment of a wide variety of infectious diseases. The stability of IgY in the orogastrointestinal tract and its safety profile has been well-documented. IgY has been used in the treatment or prevention of dental caries, periodontitis and gingivitis, gastritis and gastric ulcer, oral thrush and infant rotavirus diarrhea. The recent clinical trials on IgY with encouraging results has catapulted into the market novel nutraceutical or health supplements for therapeutic or prophylactic intervention based on the consumption of mono-specific or mixed IgY formulations. With recent trends in consumer preference for natural materials to alleviate health concerns, the increasing healthcare costs and the recent advances in drug delivery systems, IgY is likely to shift from its mainly functional food status toward pharmaceuticalization in the foreseeable future.
本述评总结了最近发表的涉及经口应用 IgY 补充食品用于特定的口腔胃肠道疾病预防和控制目的的实验室研究和临床试验。传统抗菌药物的长期使用和滥用催生了抗药性微生物，促使科学家寻找其他杀菌方法。特别是，将 IgY 作为一种使用口服鸡免疫球蛋白 (IgY) 进行被动免疫的新型免疫疗法，作为预防和治疗各种传染病的廉价非抗生素替代物引起了广泛关注。IgY 在口腔胃肠道中的稳定性及其安全性已得到充分证实。IgY 已用于治疗或预防龋齿、牙周炎和牙龈炎、胃炎和胃溃疡、口腔鹅口疮和婴儿轮状病毒腹泻。最近的 IgY 临床试验取得了令人鼓舞的结果，基于单特异性或混合 IgY 制剂的消费，为治疗或预防干预推出了新型的营养保健品或健康补充剂。鉴于消费者对天然材料的偏好日益增加，以缓解健康问题，医疗保健成本不断增加以及药物输送系统的最新进展，IgY 可能会在可预见的未来从主要的功能性食品状态向药物化转变。
