School of Life Science and Technology, Dalian University of Technology, Dalian 116024, China.
Biotechnol Adv. 2011 Nov-Dec;29(6):860-8. doi: 10.1016/j.biotechadv.2011.07.003. Epub 2011 Jul 20.
Oral administration of chicken egg yolk immunoglobulin (IgY) has attracted considerable attention as a means of controlling infectious diseases of bacterial and viral origin. Oral administration of IgY possesses many advantages compared with mammalian IgG including cost-effectiveness, convenience and high yield. This review presents an overview of the potential to use IgY immunotherapy for the prevention and treatment of terrestrial and aquatic animal diseases and speculates on the future of IgY technology. Included are a review of the potential application of IgY for the treatment of livestock diseases such as mastitis and diarrhea, poultry diseases such as Salmonella, Campylobacteriosis, infectious bursal disease and Newcastle disease, as well as aquatic diseases like shrimp white spot syndrome virus, Yersina ruckeri and Edwardsiella tarda. Some potential obstacles to the adoption of IgY technology are also discussed.
口服鸡蛋黄免疫球蛋白（IgY）作为控制细菌性和病毒性传染病的一种手段，引起了相当大的关注。与哺乳动物 IgG 相比，口服 IgY 具有许多优势，包括成本效益高、方便和产量高。本综述概述了 IgY 免疫疗法在预防和治疗陆生和水生动物疾病方面的潜力，并推测了 IgY 技术的未来。其中包括 IgY 治疗乳腺炎和腹泻等家畜疾病、沙门氏菌病、弯曲杆菌病、传染性法氏囊病和新城疫等家禽疾病以及虾白斑综合征病毒、鲁克氏耶尔森菌和迟缓爱德华菌等水产疾病的潜在应用的综述。还讨论了采用 IgY 技术的一些潜在障碍。
