Shim Lisa, Talley Nicholas J, Boyce Philip, Tennant Chris, Jones Mike, Kellow John E
Department of Gastroenterology, Royal North Shore Hospital, University of Sydney, NSW, Australia.
Scand J Gastroenterol. 2013 Mar;48(3):295-301. doi: 10.3109/00365521.2012.758767. Epub 2013 Jan 16.
Information on the relationships between stool characteristics and colonic transit time (CTT) in irritable bowel syndrome (IBS) is limited. Our aims were: (i) to relate stool frequency and consistency to total and segmental CTTs, (ii) to correlate changes in these stool characteristics with changes in CTTs between a baseline assessment and a 12-week assessment, and (iii) to examine the confounding effects of mood on these relationships, in patients with IBS.
Twenty-one female patients with IBS underwent, on two occasions 12 weeks apart, a colonic transit study and completed at these times Bristol Stool Form Scale (BSFS) and Bowel Symptoms Severity Rating Scale (BSSRS). All patients also completed the Hospital Anxiety and Depression scale.
Between baseline and the 12-week assessment, an increase in the number of days over the past week without a bowel motion correlated with prolonged total CTT (r = 0.54, p = 0.01). An increase in the number of days with more than three bowel motions per day correlated with a shorter right CTT (r = -0.52, p = 0.02). Only after adjusting for anxiety and depression, did an increase in loose or watery bowel motions (for BSSRS but not for BSFS) correlate with a shorter right CTT (r = -0.47, p = 0.03).
Stool frequency, as well as stool consistency, correlates with CTT. Correlations between stool consistency and CTT are more robust for BSSRS than for BSFS. An effect of mood appears to be important in the relationship between stool consistency and CTT.
关于肠易激综合征（IBS）患者粪便特征与结肠运输时间（CTT）之间关系的信息有限。我们的目的是：（i）将排便频率和粪便稠度与总CTT及节段性CTT相关联；（ii）将这些粪便特征的变化与基线评估和12周评估之间CTT的变化相关联；（iii）在IBS患者中研究情绪对这些关系的混杂影响。
21例女性IBS患者在间隔12周的两个时间点接受了结肠运输研究，并在此时完成了布里斯托大便形态量表（BSFS）和肠道症状严重程度评定量表（BSSRS）。所有患者还完成了医院焦虑抑郁量表。
在基线和12周评估之间，过去一周无排便天数的增加与总CTT延长相关（r = 0.54，p = 0.01）。每天排便超过3次的天数增加与右半结肠CTT缩短相关（r = -0.52，p = 0.02）。仅在对焦虑和抑郁进行校正后，松散或水样便次数的增加（基于BSSRS而非BSFS）才与右半结肠CTT缩短相关（r = -0.47，p = 0.03）。
排便频率以及粪便稠度与CTT相关。对于BSSRS，粪便稠度与CTT之间的相关性比BSFS更强。情绪影响似乎在粪便稠度与CTT的关系中起重要作用。
