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The role of mannose-6-phosphate receptor and autophagy in influencing the outcome of combination therapy.甘露糖-6-磷酸受体和自噬在影响联合治疗效果中的作用。
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2
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Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface.天花粉蛋白通过上调细胞表面的阳离子独立型甘露糖-6-磷酸受体（CI-MPR），增加颗粒酶B进入肿瘤细胞的能力。
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Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.甘露糖 6-磷酸/胰岛素样生长因子 II 受体是细胞毒性 T 细胞诱导凋亡过程中颗粒酶 B 的死亡受体。
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A novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II.胰岛素样生长因子-II（IGF-II）上一个新的人胰岛素样生长因子-II/甘露糖6-磷酸受体结合位点。
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Radiation-induced autophagy potentiates immunotherapy of cancer via up-regulation of mannose 6-phosphate receptor on tumor cells in mice.辐射诱导的自噬通过上调小鼠肿瘤细胞上的甘露糖6-磷酸受体增强癌症免疫治疗。
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Autophagy induced by conventional chemotherapy mediates tumor cell sensitivity to immunotherapy.常规化疗诱导的自噬使肿瘤细胞对免疫治疗敏感。
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Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer.化疗诱导的细胞凋亡、自噬和细胞周期停滞是上皮性卵巢癌化疗免疫治疗协同作用的关键驱动因素。
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Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis.甘露糖-6-磷酸/胰岛素样生长因子 2 受体（M6P/IGF2R）在肿瘤发生中的作用。
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引用本文的文献

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Potential therapeutic targets for colorectal cancer and its subsites: evidence from the proteome-wide Mendelian randomization analyses.结直肠癌及其亚部位的潜在治疗靶点：来自全蛋白质组孟德尔随机化分析的证据
Transl Cancer Res. 2025 Jan 31;14(1):486-496. doi: 10.21037/tcr-24-1503. Epub 2025 Jan 20.
2
Targeting autophagy can synergize the efficacy of immune checkpoint inhibitors against therapeutic resistance: New promising strategy to reinvigorate cancer therapy.靶向自噬可增强免疫检查点抑制剂对治疗耐药性的疗效：重振癌症治疗的新的有前景策略。
Heliyon. 2024 Sep 3;10(18):e37376. doi: 10.1016/j.heliyon.2024.e37376. eCollection 2024 Sep 30.
3
Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.蛋白质组学分析癌症组织鉴定 IGF2R 为喉癌潜在的治疗靶点。
Front Endocrinol (Lausanne). 2022 Oct 10;13:1031210. doi: 10.3389/fendo.2022.1031210. eCollection 2022.
4
Primary central nervous system lymphomas express immunohistochemical factors of autophagy.原发性中枢神经系统淋巴瘤表达自噬的免疫组化因子。
Sci Rep. 2021 Nov 15;11(1):22259. doi: 10.1038/s41598-021-01693-6.
5
Autophagic Markers in Chordomas: Immunohistochemical Analysis and Comparison with the Immune Microenvironment of Chordoma Tissues.脊索瘤中的自噬标志物：免疫组织化学分析及与脊索瘤组织免疫微环境的比较
Cancers (Basel). 2021 Apr 30;13(9):2169. doi: 10.3390/cancers13092169.
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Pyroptosis: mechanisms and diseases.细胞焦亡：机制与疾病。
Signal Transduct Target Ther. 2021 Mar 29;6(1):128. doi: 10.1038/s41392-021-00507-5.
7
A large-scale RNA interference screen identifies genes that regulate autophagy at different stages.大规模 RNA 干扰筛选鉴定出调控不同阶段自噬的基因。
Sci Rep. 2018 Feb 12;8(1):2822. doi: 10.1038/s41598-018-21106-5.
8
microRNA-352 regulates collateral vessel growth induced by elevated fluid shear stress in the rat hind limb.微小 RNA-352 调控大鼠后肢高流体切应力诱导的侧支血管生长。
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9
Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface.天花粉蛋白通过上调细胞表面的阳离子独立型甘露糖-6-磷酸受体（CI-MPR），增加颗粒酶B进入肿瘤细胞的能力。
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10
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.免疫原性细胞死亡中损伤相关分子模式的分子与转化分类
Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

甘露糖-6-磷酸受体和自噬在影响联合治疗效果中的作用。

The role of mannose-6-phosphate receptor and autophagy in influencing the outcome of combination therapy.

机构信息

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

出版信息

Autophagy. 2013 Apr;9(4):615-6. doi: 10.4161/auto.23485. Epub 2013 Jan 16.

DOI:10.4161/auto.23485
PMID:23324210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3627678/
Abstract

Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time of administration. We found that chemotherapy enhanced the levels of insulin-like growth factor 2 receptor/cation-independent mannose-6-phosphate receptor (IGF2R) on the surface of tumor cells, which leads to better tumor targeting by cytotoxic T cells (CTLs). Early evidence indicates that upregulation of IGF2R involves the autophagy pathway.

摘要

联合两种不同的治疗方法靶向治疗恶性肿瘤正变得越来越重要，临床前/临床结果表明，这种方法能更有效地消除肿瘤或延长缓解期。更好地理解治疗方法之间的协同作用有助于优化剂量和给药时间。我们发现化疗增强了肿瘤细胞表面胰岛素样生长因子 2 受体/阳离子非依赖性甘露糖-6-磷酸受体（IGF2R）的水平，这导致细胞毒性 T 细胞（CTL）更好地靶向肿瘤。早期证据表明，IGF2R 的上调涉及自噬途径。