甘露糖-6-磷酸受体和自噬在影响联合治疗效果中的作用。
The role of mannose-6-phosphate receptor and autophagy in influencing the outcome of combination therapy.
机构信息
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
出版信息
Autophagy. 2013 Apr;9(4):615-6. doi: 10.4161/auto.23485. Epub 2013 Jan 16.
Abstract
Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time of administration. We found that chemotherapy enhanced the levels of insulin-like growth factor 2 receptor/cation-independent mannose-6-phosphate receptor (IGF2R) on the surface of tumor cells, which leads to better tumor targeting by cytotoxic T cells (CTLs). Early evidence indicates that upregulation of IGF2R involves the autophagy pathway.
摘要
联合两种不同的治疗方法靶向治疗恶性肿瘤正变得越来越重要，临床前/临床结果表明，这种方法能更有效地消除肿瘤或延长缓解期。更好地理解治疗方法之间的协同作用有助于优化剂量和给药时间。我们发现化疗增强了肿瘤细胞表面胰岛素样生长因子 2 受体/阳离子非依赖性甘露糖-6-磷酸受体（IGF2R）的水平，这导致细胞毒性 T 细胞（CTL）更好地靶向肿瘤。早期证据表明，IGF2R 的上调涉及自噬途径。
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