Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA.
Viruses. 2013 Jan 16;5(1):226-40. doi: 10.3390/v5010226.
Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1's role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.
EB 病毒核抗原 1（EBNA1）是由 EBV 编码的一种多功能蛋白。EBNA1 在维持潜伏增殖细胞中的 EBV 方面发挥作用，通过介导 EBV 基因组合成和非随机分配到子细胞，以及调节病毒基因转录，其作用已得到很好的描述。然而，EBNA1 在影响宿主细胞以提供对那些携带 EBV 的细胞的选择性优势方面的作用还不太清楚。在这篇综述中，我们将重点关注 EBNA1 与宿主细胞之间的相互作用，这些相互作用可能为 EBV 感染细胞提供除了维持 EBV 之外的选择性优势。
