TAM 受体 Axl 是否是淋巴细胞脉络丛脑膜炎病毒的受体？
Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?
机构信息
Viral-Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
出版信息
J Virol. 2013 Apr;87(7):4071-4. doi: 10.1128/JVI.03268-12. Epub 2013 Jan 16.
Abstract
A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.
摘要
最近的一篇出版物表明，细胞受体 Axl 的过表达会负调控 Toll 样受体信号，从而增强体外带有淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 糖蛋白的病毒假型的进入。在测试这些观察结果的生物学相关性时，我们发现 Axl(-/-)和野生型小鼠的 LCMV 感染之间的病毒动力学没有差异，也没有在自发清除病毒之前的 T 细胞反应的差异。因此，Axl 对于 LCMV 感染小鼠并非必需。
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