Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States of America.
PLoS One. 2013;8(1):e53607. doi: 10.1371/journal.pone.0053607. Epub 2013 Jan 11.
While post-treatment breast cancer survivors face up to twice the cancer risk of the general population, modifiable health behaviors may somewhat reduce this risk. We sought to better understand health behaviors that early stage breast cancer survivors engage in to reduce recurrence risk.
Data came from a cross-sectional multi-site survey of 186 early-stage breast cancer survivors who received genomic testing for breast cancer recurrence risk (Oncotype DX) during their clinical care. Study outcomes were meeting health behavior recommendations (daily fruit and vegetable intake, regular physical activity, and having a healthy body mass index (BMI)).
Approximately three-quarters of survivors we surveyed believed the 3 behaviors might reduce their cancer risk but many did not engage in these behaviors for this purpose: 62% for BMI, 36% for fruit and vegetable consumption, and 37% for physical activity. Survivors with higher recurrence risk, as indicated by their genomic test results, were no more likely to meet any of the three health behavior recommendations. Adherence to health behavior recommendations was higher for women who were white, college-educated, and had higher incomes.
Many nonadherent breast cancer survivors wish to use these behavioral strategies to reduce their risk for recurrence, suggesting an important opportunity for intervention. Improving BMI, which has the largest association with cancer risk, is an especially promising target.
尽管治疗后的乳腺癌幸存者面临的癌症风险是普通人群的两倍，但可改变的健康行为可能会在一定程度上降低这种风险。我们试图更好地了解早期乳腺癌幸存者为降低复发风险而采取的健康行为。
数据来自对 186 名接受乳腺癌复发风险（Oncotype DX）基因组检测的早期乳腺癌幸存者的横断面多地点调查。研究结果是符合健康行为建议（每天摄入水果和蔬菜、定期进行体育锻炼、保持健康的体重指数（BMI））。
我们调查的幸存者中，约有四分之三的人认为这 3 种行为可能降低他们的癌症风险，但许多人并没有出于这个目的而采取这些行为：62%的人是为了 BMI，36%的人是为了摄入水果和蔬菜，37%的人是为了进行体育锻炼。根据基因组检测结果，复发风险较高的幸存者不太可能符合任何 3 项健康行为建议。坚持健康行为建议的人，其种族为白种人、受过大学教育、收入较高。
许多不遵守健康行为的乳腺癌幸存者希望使用这些行为策略来降低复发风险，这表明有一个重要的干预机会。改善 BMI，这与癌症风险的关联最大，是一个特别有希望的目标。
